在健康的老年人中，自我评定的睡眠质量差与全身炎症升高有关吗？
Is poor self-rated sleep quality associated with elevated systemic inflammation in healthy older adults?
作者信息
Petrov Kimberley Kira, Hayley Amie, Catchlove Sarah, Savage Karen, Stough Con
机构信息
Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia.
Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia; Institute for Breathing and Sleep (IBAS), Austin Health Hospital, Melbourne, Australia.
出版信息
Mech Ageing Dev. 2020 Dec;192:111388. doi: 10.1016/j.mad.2020.111388. Epub 2020 Oct 17.
OBJECTIVE
Examine subjective sleep quality and inflammation among healthy older adults participating in the Australian Research Council Longevity Intervention (ARCLI).
METHODS
Data was taken from a sub-set of 232 participants aged between 60-70 years (M = 65.88 ± SD 4.08 years) who participated in the baseline assessment phase of the Australian Research Council Longevity Intervention (ARCLI) study. Subjective sleep was assessed via the Leeds Sleep Evaluation Questionnaire (LSEQ). Inflammatory markers (TNF-α, IL-1β, IL-6, IL-10, IL-2, IFN-γ, IL-4, hs-CRP) were derived from whole blood. Correlation and multiple regression analyses were used to examine associations between each of the four sleep outcome variables and inflammatory outcomes, examined as a group and following gender stratification.
RESULTS
Difficulties getting to sleep were independently associated with higher IL-2 [F = 4.62, adjusted R = 0.02, p = 0.03] and IL-1β [F = 8.52, adjusted R = 0.05, p = 0.004] (whole group). Difficulties getting to sleep were associated with greater IL-1β [males: F = 7.36, adjusted R = 0.097 p = 0.009; females: F = 4.25, R = 0.038, p = 0.04], and negatively associated with hs-CRP (women) [F = 4.71, R = 0.028, p = 0.032].
DISCUSSION
Subjective sleep-onset difficulties are associated with systemic inflammation.
目的
研究参与澳大利亚研究理事会长寿干预项目（ARCLI）的健康老年人的主观睡眠质量与炎症情况。
方法
数据取自232名年龄在60至70岁之间（M = 65.88 ±标准差4.08岁）的参与者子集，他们参与了澳大利亚研究理事会长寿干预项目（ARCLI）研究的基线评估阶段。通过利兹睡眠评估问卷（LSEQ）评估主观睡眠。炎症标志物（肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-6、白细胞介素-10、白细胞介素-2、干扰素-γ、白细胞介素-4、高敏C反应蛋白）取自全血。采用相关性和多元回归分析来检验四个睡眠结果变量与炎症结果之间的关联，将其作为一个整体进行检验，并按性别分层。
结果
入睡困难与较高的白细胞介素-2 [F = 4.62，调整后R = 0.02，p = 0.03]和白细胞介素-1β [F = 8.52，调整后R = 0.05，p = 0.004]独立相关（整个组）。入睡困难与更高的白细胞介素-1β相关[男性：F = 7.36，调整后R = 0.097，p = 0.009；女性：F = 4.25，R = 0.038，p = 0.04]，且与高敏C反应蛋白呈负相关（女性）[F = 4.71，R = 0.028，p = 0.032]。
讨论
主观入睡困难与全身炎症有关。
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