Li Hongzhu, Zhang Yu, Lu Liming, Yi Wei
Medical College of Acupuncture and Rehabilitation.
Clinical Research Center, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong.
Medicine (Baltimore). 2020 Oct 16;99(42):e22624. doi: 10.1097/MD.0000000000022624.
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder involving hyperandrogenism, menstrual disorder, metabolic problems, infertility, obesity, and acne. The main aim of this study was to assess the reporting quality of clinical practice guidelines (CPGs) in the field of PCOS to provide a reporting specification for this study.
We evaluated the reporting quality of clinical guidelines of PCOS using the Reporting Items for Practice Guidelines in HealThcare (RIGHT) checklist. Nine databases and 3 medical associations were searched. These included Medline, Embase, PubMed, National Institute for Health and Care Excellence (NICE), Guidelines International Network (GIN), National Guideline Clearinghouse (NGC), China National Knowledge Infrastructure, Wanfang and Chinese Science, and Technology Journal Database (VIP). Three medical associations included the European Society of Human Reproduction and Embryology, the American Society for Reproductive Medicine and the Agency for Healthcare Research and Quality. Two independent authors assessed the reporting quality of PCOS CPGs by the RIGHT checklist, and Spearman's correlation was used to assess inter-rater reliability.
Twelve PCOS CPGs were included. On average, 20.0 (57.1%) of the 35 items in the RIGHT checklist were reported. All items were fully reported by one of these CPGs. The number of reported items ranged from 10 (28.6%) to 35 (100%). Overall, 16.7%, 66.7%, and 16.7% of included guidelines were of high, medium, and low quality, respectively. The reporting proportions of the 7 domains (i.e., Basic information, Background, Evidence, Recommendations, Reviewand quality assurance, Funding and declaration and management of interests, and Other information) in the RIGHT checklist were 62.0%, 69.1%, 53.3%, 60.7%, 33.3%, 31.2%, and 69.4%, respectively.
The evaluation of these CPGs by the RIGHT checklist revealed that the reporting quality varied among guidelines. Low quality items were the processes of evidence decision and the declaration of funding in most included CPGs. Guideline developers should pay more attention to these items to disseminate and implement better guidelines in near future.
registration at PROSPERO CRD42020163435.
多囊卵巢综合征（PCOS）是一种常见的内分泌紊乱疾病，涉及高雄激素血症、月经紊乱、代谢问题、不孕、肥胖和痤疮。本研究的主要目的是评估PCOS领域临床实践指南（CPG）的报告质量，为该研究提供报告规范。
我们使用医疗保健实践指南报告条目（RIGHT）清单评估PCOS临床指南的报告质量。检索了9个数据库和3个医学协会。这些包括Medline、Embase、PubMed、英国国家卫生与临床优化研究所（NICE）、指南国际网络（GIN）、美国国家指南交换中心（NGC）、中国知网、万方和维普中文科技期刊数据库。3个医学协会包括欧洲人类生殖与胚胎学会、美国生殖医学学会和医疗保健研究与质量局。两名独立作者通过RIGHT清单评估PCOS CPG的报告质量，并使用Spearman相关性评估评分者间的可靠性。
纳入了12份PCOS CPG。RIGHT清单中的35项内容平均报告了20.0项（57.1%）。其中一份CPG报告了所有项目。报告项目的数量从10项（28.6%）到35项（100%）不等。总体而言，纳入的指南中分别有16.7%、66.7%和16.7%为高质量、中等质量和低质量。RIGHT清单中7个领域（即基本信息、背景、证据、推荐意见、审核与质量保证、资金来源及利益声明与管理、其他信息）的报告比例分别为62.0%、69.1%、53.3%、60.7%、33.3%、31.2%和69.4%。
通过RIGHT清单对这些CPG进行评估发现，各指南的报告质量存在差异。大多数纳入的CPG中，低质量项目是证据决策过程和资金声明。指南制定者应更多关注这些项目，以便在不久的将来更好地传播和实施指南。
在国际前瞻性注册系统（PROSPERO）注册，注册号为CRD42020163435。
