肿瘤标志物的基因与人类染色体上的细胞原癌基因聚集在一起。

Genes for tumor markers are clustered with cellular proto-oncogenes on human chromosomes.

作者信息

Hozier J C, Mass M J, Siegfried J M

机构信息

Medical Genetics Laboratory, Florida Institute of Technology, Melbourne 32901.

出版信息

Cancer Lett. 1987 Sep;36(3):235-45. doi: 10.1016/0304-3835(87)90016-4.

DOI:10.1016/0304-3835(87)90016-4

PMID:3308073

Abstract

We have analyzed the relative mapping positions of genes for polypeptides expressed abnormally in tumors (tumor markers) and cellular proto-oncogenes and find a remarkable degree of co-mapping of tumor marker genes with oncogenes in the human karyotype. We propose that aberrant expression of marker genes in tumors may be related to their proximity in the human genome to oncogenes expressed during the development of malignancy, and we suggest ways to test this hypothesis of concerted abnormal gene expression in mammalian tumor cells.

摘要

我们分析了在肿瘤中异常表达的多肽（肿瘤标志物）基因与细胞原癌基因的相对定位，发现在人类核型中肿瘤标志物基因与癌基因存在显著程度的共定位。我们提出，肿瘤中标志物基因的异常表达可能与其在人类基因组中与恶性肿瘤发生过程中表达的癌基因的接近程度有关，并且我们提出了检验哺乳动物肿瘤细胞中协同异常基因表达这一假说的方法。