Kastury K, Li J, Druck T, Su H, Vogt P K, Croce C M, Huebner K
Jefferson Cancer Institute, Jefferson Medical College, Philadelphia, PA 19107.
Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3616-8. doi: 10.1073/pnas.91.9.3616.
Chromosomal mapping of the human QIN gene (renamed FKH2 by the Human Genome Organization Nomenclature Committee) was initially accomplished by correlation of the presence of the QIN locus with specific chromosome regions in a rodent-human hybrid panel. This analysis revealed that the human QIN gene maps to chromosome region 14q11.2-->14q32, between the TCR and IGH loci. Further analysis by fluorescence in situ hybridization techniques with a human QIN genomic clone refined the human QIN gene localization to 14q13.
人类QIN基因(人类基因组组织命名委员会将其重新命名为FKH2)的染色体定位最初是通过在啮齿动物-人类杂交细胞系中,将QIN基因座的存在与特定染色体区域进行关联来完成的。该分析表明,人类QIN基因定位于14号染色体区域14q11.2→14q32,位于TCR和IGH基因座之间。使用人类QIN基因组克隆通过荧光原位杂交技术进行的进一步分析,将人类QIN基因定位精确到了14q13。