自噬：对其在癌症进展和耐药性中作用的新见解
Autophagy: New Insights into Its Roles in Cancer Progression and Drug Resistance.
作者信息
Nawrocki Steffan T, Wang Wei, Carew Jennifer S
机构信息
University of Arizona Cancer Center, Tucson, AZ 85724, USA.
Division of Translational and Regenerative Medicine, Department of Medicine, University of Arizona, Tucson, AZ 85721, USA.
出版信息
Cancers (Basel). 2020 Oct 16;12(10):3005. doi: 10.3390/cancers12103005.
Abstract
Autophagy is a mechanism of lysosomal proteolysis that is utilized to degrade damaged organelles, proteins, and other cellular components. Although key studies demonstrate that autophagy functions as a mechanism of tumor suppression via the degradation of defective pre-malignant cells, autophagy can also be used as a mechanism to break down cellular components under stress conditions to generate the required metabolic materials for cell survival. Autophagy has emerged as an important mediator of resistance to radiation, chemotherapy, and targeted agents. This series of articles highlight the role of autophagy in cancer progression and drug resistance and underscores the need for new and more effective agents that target this process.
摘要
自噬是一种溶酶体蛋白水解机制，用于降解受损的细胞器、蛋白质和其他细胞成分。尽管关键研究表明自噬通过降解有缺陷的癌前细胞发挥肿瘤抑制作用，但自噬也可作为一种机制，在应激条件下分解细胞成分，以产生细胞存活所需的代谢物质。自噬已成为对放疗、化疗和靶向药物耐药的重要介导因素。本系列文章强调了自噬在癌症进展和耐药中的作用，并强调需要新的、更有效的靶向这一过程的药物。
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