直面胃癌中的细胞自噬——我们目前了解多少？
Facing Cell Autophagy in Gastric Cancer - What Do We Know so Far?
作者信息
Xiu Ting, Guo Qie, Jing Fan-Bo
机构信息
Department of Clinical Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, People's Republic of China.
Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, 266021, People's Republic of China.
出版信息
Int J Gen Med. 2021 May 3;14:1647-1659. doi: 10.2147/IJGM.S298705. eCollection 2021.
Abstract
Autophagy is a process by which misfolded proteins and damaged organelles in the lysosomes of tumor cells were degraded reusing decomposed substances and avoiding accumulation of large amounts of harmful substances. Here, the role of autophagy in the development of malignant transformation of gastric tumors, and the underlying mechanisms involved in autophagy formation, and the application of targeted autophagy in the treatment of gastric cancer were summarized.
摘要
自噬是一个过程，通过该过程肿瘤细胞溶酶体中错误折叠的蛋白质和受损的细胞器被降解，重新利用分解后的物质，避免大量有害物质的积累。在此，总结了自噬在胃肿瘤恶性转化发展中的作用、自噬形成所涉及的潜在机制以及靶向自噬在胃癌治疗中的应用。
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