Clinical and drug resistance characteristics of infections in 76 patients.

OBJECTIVES

To investigate the clinical and drug resistance characteristics of infections in the Huainan region of Anhui and provide a reference for the clinical selection of antimicrobial agents.

METHODS

This single-center retrospective analysis included 76 patients with infection in Huainan during the period from October 2018 to March 2020. The hospital department in which the patients were treated and the drug susceptibility characteristics of the isolates were recorded.

RESULTS

Among the 76 patients, the lung was the most common site of infection, and intensive care unit was the main hospital department. Extended spectrum beta-lactamase screening revealed expression by all 76 isolates of . Of the 76 isolates, 92.1% exhibited multiple drug resistance or extensive drug resistance. isolates were sensitive to cefepime and imipenem, but not to other beta-lactam antibiotics. Twenty isolates were resistant to all 21 types of antibiotics. Of the 20 patients infected with extensively drug-resistant isolates, nine (45%) died.

CONCLUSIONS

Drug resistance is increasing in . The antimicrobial agent imipenem may be effective for treatment of infections. Fluoroquinolones, aminoglycosides, and fourth-generation cephalosporins are suitable options for antibiotic therapy.