Liu Jiachang, Wang Ruikai, Fang Ming
Department of Respiratory Medicine, First Affiliated Hospital of Anhui University of Science & Technology, Huainan, China.
J Int Med Res. 2020 Oct;48(10):300060520962296. doi: 10.1177/0300060520962296.
To investigate the clinical and drug resistance characteristics of infections in the Huainan region of Anhui and provide a reference for the clinical selection of antimicrobial agents.
This single-center retrospective analysis included 76 patients with infection in Huainan during the period from October 2018 to March 2020. The hospital department in which the patients were treated and the drug susceptibility characteristics of the isolates were recorded.
Among the 76 patients, the lung was the most common site of infection, and intensive care unit was the main hospital department. Extended spectrum beta-lactamase screening revealed expression by all 76 isolates of . Of the 76 isolates, 92.1% exhibited multiple drug resistance or extensive drug resistance. isolates were sensitive to cefepime and imipenem, but not to other beta-lactam antibiotics. Twenty isolates were resistant to all 21 types of antibiotics. Of the 20 patients infected with extensively drug-resistant isolates, nine (45%) died.
Drug resistance is increasing in . The antimicrobial agent imipenem may be effective for treatment of infections. Fluoroquinolones, aminoglycosides, and fourth-generation cephalosporins are suitable options for antibiotic therapy.
调查安徽淮南地区感染的临床及耐药特征，为临床选择抗菌药物提供参考。
本单中心回顾性分析纳入了2018年10月至2020年3月期间淮南市76例感染患者。记录患者接受治疗的医院科室以及分离株的药敏特征。
76例患者中肺部是最常见的感染部位，重症监护病房是主要的收治科室。超广谱β-内酰胺酶筛查显示76株分离株均表达。76株分离株中，92.1%表现出多重耐药或广泛耐药。分离株对头孢吡肟和亚胺培南敏感，但对其他β-内酰胺类抗生素不敏感。20株分离株对所有21种抗生素均耐药。在20例感染广泛耐药分离株的患者中，9例（45%）死亡。
感染的耐药性正在增加。抗菌药物亚胺培南可能对感染治疗有效。氟喹诺酮类、氨基糖苷类和第四代头孢菌素是抗生素治疗的合适选择。
