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感染的临床及耐药特征

Clinical and Drug Resistance Characteristics of Infections.

作者信息

Malviya Meenal, Kale-Pradhan Pramodini, Coyle Meredith, Giuliano Christopher, Johnson Leonard B

机构信息

Division of Infectious Diseases, Henry Ford St. John Hospital, 22101 Morsoss Road, Detroit, MI 48236, USA.

Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.

出版信息

Microorganisms. 2024 Oct 18;12(10):2085. doi: 10.3390/microorganisms12102085.

Abstract

is a G ram-negative bacillus that most frequently colonizes the urinary tract and is often resistant to many antimicrobials. This study aimed to evaluate the resistance patterns of spp. and clinical outcomes due to the paucity of data. A multi-center, descriptive, retrospective chart review of adult patients with spp. infections was conducted from 1 January 2020 to 31 May 2022. The primary outcome was to describe the drug resistance patterns of spp. isolates. This study's secondary outcome was to evaluate the clinical outcomes of patients with spp. infections. Of the 312 patients screened, 244 were excluded primarily for polymicrobial infections. The mean age was 70 years, and 39 (56.5%) were males. Of the 68 included cases, 46 (67.6%) were , 20 (29.4%) were , and 2 (2.9%) were . The most common infections were bacteremia 38 (55.8%), followed by 27 (39.7%) urinary tract infections and 3 (4.4%) wound infections. In this study, 45 patients (65.2%) had urinary catheters. The primary antibiotics used for treatment consisted of ceftriaxone (25 (36.2%)), cefepime (20 (29%)), and meropenem (10 (14.5%)). Only 5 of 68 (7.2%) cases were multidrug- resistant and required meropenem. In total, 19 patients (27.1%) died during their admission, but none were related to Providencia infections. A total of 10 of the 68 patients (14.5%) were readmitted within 30 days for reasons unrelated to the progression or recurrence of Providencia infections. bacteremia is predominantly seen in elderly patients. Third- generation cephalosporins remain an appropriate choice of antibiotics for spp. was the only species with multidrug resistance.

摘要

是一种革兰氏阴性杆菌,最常定植于泌尿道,且常常对多种抗菌药物耐药。由于数据匮乏,本研究旨在评估 菌的耐药模式及临床结局。对2020年1月1日至2022年5月31日期间患有 菌感染的成年患者进行了一项多中心、描述性、回顾性图表审查。主要结局是描述 菌分离株的耐药模式。本研究的次要结局是评估 菌感染患者的临床结局。在筛查的312例患者中,244例主要因混合感染被排除。平均年龄为70岁,39例(56.5%)为男性。在纳入的68例病例中,46例(67.6%)为 菌,20例(29.4%)为 菌,2例(2.9%)为 菌。最常见的感染是菌血症38例(55.8%),其次是尿路感染27例(39.7%)和伤口感染3例(4.4%)。在本研究中,45例患者(65.2%)有导尿管。用于治疗的主要抗生素包括头孢曲松(25例(36.2%))、头孢吡肟(20例(29%))和美罗培南(10例(14.5%))。68例中仅有5例(7.2%)为多重耐药,需要使用美罗培南。共有19例患者(27.1%)在住院期间死亡,但均与普罗威登斯菌感染无关。68例患者中共有10例(14.5%)在30天内因与普罗威登斯菌感染进展或复发无关的原因再次入院。 菌血症主要见于老年患者。第三代头孢菌素仍然是治疗 菌的合适抗生素选择。 菌是唯一具有多重耐药性的菌种。

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本文引用的文献

1
Clinical and drug resistance characteristics of infections in 76 patients.76例患者感染的临床及耐药特征
J Int Med Res. 2020 Oct;48(10):300060520962296. doi: 10.1177/0300060520962296.

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