接受肾移植患者的恶性肿瘤病理学
[Malignant neoplastic pathology in patients given a kidney transplant].
作者信息
Prati G F, Recchia G, Dean P, Boschiero L, Faccincani L, Muolo A
机构信息
Regione Veneto-ULSS 25, Centro Ospedaliero di Borgo Trento.
出版信息
Chir Ital. 1987 Jun;39(3):298-302.
The incidence of malignant neoplasms in patients subjected to pharmacological immunosuppression following kidney transplantation is higher than that observed in the control population at large. In our unit, in a study population of 451 patients undergoing a total of 462 kidney transplants over the period from 1968 to 1986, four malignant neoplasms (0.9%) were observed in 3/369 (0.8%) patients treated with azathioprine (1 ovarian papilliferous cystoadenoma, 1 embryonal carcinoma of the testicle and 1 Kaposi's sarcoma) and in 1/93 (1.1%) patients treated with cyclosporin (1 Kaposi's sarcoma). The neoplasm was successfully controlled only in the first case after bilateral extended adnexectomy.
肾移植后接受药物免疫抑制治疗的患者中恶性肿瘤的发生率高于总体对照人群。在我们单位，在1968年至1986年期间共进行了462例肾移植的451例患者的研究群体中，在369例接受硫唑嘌呤治疗的患者中有3例（0.8%）出现了4例恶性肿瘤（0.9%）（1例卵巢乳头状囊腺瘤、1例睾丸胚胎癌和1例卡波西肉瘤），在93例接受环孢素治疗的患者中有1例（1.1%）出现了1例卡波西肉瘤。仅在第一例患者进行双侧附件广泛切除术后，肿瘤得到了成功控制。
Zotero 插件