Shah Aditi, Hajipour Mohammadreza, Allen A J Hirsch, Ayas Najib, Kendzerska Tetyana, Hanly Patrick, Kimoff John, Series Frederic, Lajoie Annie, Robillard Rebecca, Jen Rachel, Beaudin Andrew E, Raneri Jill, Skomro Robert
Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Brititsh Columbia, Canada.
Leon Judah Blackmore Sleep Disorders Program, UBC Hospital, Vancouver, Brititsh Columbia, Canada.
Sleep Adv. 2025 Jun 9;6(2):zpaf028. doi: 10.1093/sleepadvances/zpaf028. eCollection 2025 Apr.
There is a higher risk of cardiovascular disease (CVD) in patients with obstructive sleep apnea (OSA) and innate immunity is a potential pathophysiologic pathway. The objective of this study was to determine whether nocturnal hypoxemia is associated with circulating markers of innate immunity in OSA.
This was a cross-sectional study of an observational cohort from the multicentre, clinic-based, Canadian Sleep and Circadian Network. Oxygen desaturation index 4% (ODI4%) was used to diagnose and determine the severity of OSA. The percentage of time spent below SpO <90% (T90) and minimum SpO we considered as other measures of nocturnal hypoxemia. Multiple linear regressions were used to assess associations between total white blood cell (WBC) and subsets and ODI and hypoxemia indices.
A total of 1296 patients were included in the analysis. There was a positive association between ODI4% and lymphocyte count, adjusting for confounders. For every 1- increase in ODI4%, lymphocyte counts increased by 0.08 × 10 L (95% CI 0.01 to 0.15) . Patients with severe OSA (ODI4% ≥ 30 events/hour) had significantly higher total WBC and lymphocyte count than non-OSA cohort, in the adjusted model, -value <.02, for both. There was a positive association between T90 and total WBC, neutrophil, lymphocyte, and monocyte count, adjusting for confounders. Minimum SpO was independently associated with total WBC, neutrophil, and monocyte counts.
In this pan-Canadian clinic-based cohort of individuals with suspected OSA, nocturnal hypoxemia indices were associated with an increase in total WBC and subset counts.
阻塞性睡眠呼吸暂停（OSA）患者患心血管疾病（CVD）的风险更高，先天免疫是一条潜在的病理生理途径。本研究的目的是确定夜间低氧血症是否与OSA患者的先天免疫循环标志物相关。
这是一项对来自多中心、基于诊所的加拿大睡眠与昼夜节律网络的观察性队列进行的横断面研究。采用氧饱和度下降指数4%（ODI4%）来诊断和确定OSA的严重程度。将低于SpO<90%的时间百分比（T90）和最低SpO视为夜间低氧血症的其他指标。采用多元线性回归评估总白细胞（WBC）及其亚群与ODI和低氧血症指标之间的关联。
共有1296例患者纳入分析。校正混杂因素后，ODI4%与淋巴细胞计数呈正相关。ODI4%每增加1次/小时，淋巴细胞计数增加0.08×10⁹/L（95%CI 0.01至0.15）。在调整模型中，重度OSA（ODI4%≥30次/小时）患者的总WBC和淋巴细胞计数显著高于非OSA队列，两者p值均<.02。校正混杂因素后，T90与总WBC、中性粒细胞、淋巴细胞和单核细胞计数呈正相关。最低SpO与总WBC、中性粒细胞和单核细胞计数独立相关。
在这个基于加拿大诊所的疑似OSA患者队列中，夜间低氧血症指标与总WBC及其亚群计数增加相关。
