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一种用于研究[具体药物名称1]和[具体药物名称2]治疗心脑血管疾病协同机制的网络药理学技术。 （你提供的原文中药物名称缺失，我按照格式翻译了，但实际需补充完整药物名）

A Network Pharmacology Technique to Investigate the Synergistic Mechanisms of and in Treatment of Cardio-Cerebral Vascular Diseases.

作者信息

Ma Yang, Wang Wenjun, Yang Jiani, Zhang Sha, Li Zhe, Li Fei, Huang Shaojie, Lei Lu, Wang Kai, Wen Aidong, Ding Yi

机构信息

College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.

Department of Pharmacy, Xijing Hospital of the Fourth Military Medical University, Xi'an, China.

出版信息

Evid Based Complement Alternat Med. 2020 Oct 5;2020:6937186. doi: 10.1155/2020/6937186. eCollection 2020.

DOI:10.1155/2020/6937186
PMID:33082828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7566220/
Abstract

OBJECTIVE

This study is aimed to analyze the active ingredients, drug targets, and related pathways in the combination of (SM) and (RP) in the treatment of cardio-cerebral vascular diseases (CCVDs).

METHOD

The ingredients and targets of SM and RP were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the disease targets were obtained from Therapeutic Target Database (TTD), National Center for Biotechnology Information (NCBI), and Online Mendelian Inheritance in Man (OMIM) Database. The synergistic mechanisms of the SM and RP were evaluated by gene ontology (GO) enrichment analyses and Kyoto encyclopedia of genes and genomes (KEGG) path enrichment analyses.

RESULT

A total of 61 active ingredients and 58 common targets were identified in this study. KEGG pathway enrichment analysis results showed that SM- and RP-regulated pathways were mainly inflammatory processes, immunosuppression, and cardiovascular systems. The component-target-pathway network indicated that SM and RP exert a synergistic mechanism for CCVDs through PTGS2 target in PI3k-Akt, TNF, and Jak-STAT signaling pathways.

CONCLUSION

In summary, this study clarified the synergistic mechanisms of SM and RP, which can provide a better understanding of effect in the treatment of CCVDs.

摘要

目的

本研究旨在分析丹参（SM）和人参（RP）联合治疗心脑血管疾病（CCVDs）的活性成分、药物靶点及相关通路。

方法

从中药系统药理学数据库与分析平台（TCMSP）获取SM和RP的成分及靶点，从治疗靶点数据库（TTD）、美国国立生物技术信息中心（NCBI）和人类孟德尔遗传在线（OMIM）数据库获取疾病靶点。通过基因本体（GO）富集分析和京都基因与基因组百科全书（KEGG）通路富集分析评估SM和RP的协同机制。

结果

本研究共鉴定出61种活性成分和58个共同靶点。KEGG通路富集分析结果表明，SM和RP调节的通路主要是炎症过程、免疫抑制和心血管系统。成分-靶点-通路网络表明，SM和RP通过PI3k-Akt、TNF和Jak-STAT信号通路中的PTGS2靶点对CCVDs发挥协同作用机制。

结论

总之，本研究阐明了SM和RP的协同机制，有助于更好地理解其在CCVDs治疗中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118f/7566220/a16cc8be5cce/ECAM2020-6937186.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118f/7566220/10781893b638/ECAM2020-6937186.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118f/7566220/e53f742c4fe9/ECAM2020-6937186.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118f/7566220/89e3a40c02c9/ECAM2020-6937186.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118f/7566220/b6c7b7e3b79c/ECAM2020-6937186.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118f/7566220/a16cc8be5cce/ECAM2020-6937186.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118f/7566220/10781893b638/ECAM2020-6937186.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118f/7566220/e53f742c4fe9/ECAM2020-6937186.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118f/7566220/89e3a40c02c9/ECAM2020-6937186.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118f/7566220/b6c7b7e3b79c/ECAM2020-6937186.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/118f/7566220/a16cc8be5cce/ECAM2020-6937186.005.jpg

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