从尿液中的代谢产物估计，戒酒期间酗酒者体内前列腺素E和前列环素的全身生成减少，而血栓素生成未变。

Decreased systemic formation of prostaglandin E and prostacyclin, and unchanged thromboxane formation, in alcoholics during withdrawal as estimated from metabolites in urine.

Förstermann U, Feuerstein T J

Department of Clinical Pharmacology, Hannover Medical School, Federal Republic of Germany.

Clin Sci (Lond). 1987 Sep;73(3):277-83. doi: 10.1042/cs0730277.

Abstract

The rates of secretion into the circulation of prostaglandin E, prostacyclin, and thromboxane A2 were estimated in male alcoholics on the third day of withdrawal and in control subjects by measuring appropriate metabolites in urine. 2. Urinary levels of tetranor-5,11-diketo-7 alpha-hydroxyprostane-1,16-dioic acid (the major urinary metabolite of prostaglandins E1 and E2), of 2,3-dinor-6-keto-prostaglandin F1 alpha (the major urinary metabolite of prostacyclin) and of 6-keto-prostaglandin F1 alpha (the stable hydrolysis product of prostacyclin) were significantly different from the normal subjects in the alcoholic group. In contrast, 2,3-dinor-thromboxane B2 (the major urinary metabolite of thromboxane A2) and thromboxane B2 (the stable hydrolysis product of thromboxane A2) were not significantly different between the groups. 3. These data suggest that the ratio of the vasodilator prostanoids prostaglandin E and prostacyclin and the vasoconstrictor prostanoid thromboxane A2 is lower than in normal subjects, in alcoholics during withdrawal. This may be one causal factor for the higher incidence of hypertension observed in withdrawing alcoholics compared with control subjects.

摘要

通过测量尿液中的相应代谢产物，对男性酗酒者戒断第三天及对照组受试者前列腺素E、前列环素和血栓素A2的循环分泌率进行了估算。2. 四去甲-5,11-二酮-7α-羟基前列腺烷-1,16-二酸（前列腺素E1和E2的主要尿液代谢产物）、2,3-二去甲-6-酮-前列腺素F1α（前列环素的主要尿液代谢产物）和6-酮-前列腺素F1α（前列环素的稳定水解产物）的尿液水平在酒精组中与正常受试者有显著差异。相比之下，2,3-二去甲-血栓素B2（血栓素A2的主要尿液代谢产物）和血栓素B2（血栓素A2的稳定水解产物）在两组之间没有显著差异。3. 这些数据表明，在酗酒者戒断期间，血管舒张性前列腺素类物质前列腺素E和前列环素与血管收缩性前列腺素类物质血栓素A2的比例低于正常受试者。这可能是与对照组相比，戒断期酗酒者高血压发病率较高的一个因果因素。