Neiman J, Hillbom M, Benthin G, Anggård E E
J Clin Pathol. 1987 May;40(5):512-5. doi: 10.1136/jcp.40.5.512.
The excretion of 2,3-dinor-6-keto prostaglandin F1 alpha, a major urinary metabolite of prostacyclin, and the formation of thromboxane B2, a stable metabolite of thromboxane A2, by platelets stimulated by adenosine diphosphate, were studied in alcoholics, who had been admitted for detoxification. Once prolonged heavy drinking had stopped, platelet count and thromboxane formation, calculated either per 10(7) platelets or per litre of blood, significantly increased (p less than 0.05), while the skin bleeding time and urinary excretion of the metabolite of prostacyclin decreased (p less than 0.05). The balance between prostacyclin and thromboxane therefore seemed to favour the excretion of prostacyclin while it shifted to favour thromboxane formation about a week later.
对因戒酒入院的酗酒者进行了研究，观察二磷酸腺苷刺激血小板后，前列环素的主要尿液代谢产物2,3-二去甲-6-酮前列腺素F1α的排泄情况，以及血栓素A2的稳定代谢产物血栓素B2的生成情况。一旦长期大量饮酒停止，以每10⁷个血小板或每升血液计算，血小板计数和血栓素生成显著增加（p<0.05），而皮肤出血时间和前列环素代谢产物的尿液排泄减少（p<0.05）。因此，前列环素和血栓素之间的平衡似乎在饮酒停止时有利于前列环素的排泄，而在大约一周后则转向有利于血栓素的生成。
