Bao Riyue, Friedrich Markus
Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
PeerJ. 2020 Oct 12;8:e10012. doi: 10.7717/peerj.10012. eCollection 2020.
Gene duplication is an important source of evolutionary innovation. To explore the relative impact of gene duplication during the diversification of major insect model system lineages, we performed a comparative analysis of lineage-specific gene duplications in the fruit fly (Diptera: Brachycera), the mosquito ae (Diptera: Culicomorpha), the red flour beetle (Coleoptera), and the honeybee (Hymenoptera). Focusing on close to 6,000 insect core gene families containing maximally six paralogs, we detected a conspicuously higher number of lineage-specific duplications in (689) compared to (315), (386), and (223). Based on analyses of sequence divergence, phylogenetic distribution, and gene ontology information, we present evidence that an increased background rate of gene duplicate accumulation played an exceptional role during the diversification of the higher Diptera (Brachycera), in part by providing enriched opportunities for intralocus sexual conflict resolution, which may have boosted speciation rates during the early radiation of the megadiverse brachyceran subclade Schizophora.
基因复制是进化创新的一个重要来源。为了探究在主要昆虫模型系统谱系多样化过程中基因复制的相对影响，我们对果蝇（双翅目：短角亚目）、按蚊（双翅目：蚊亚科）、赤拟谷盗（鞘翅目）和蜜蜂（膜翅目）中谱系特异性基因复制进行了比较分析。聚焦于近6000个最多包含6个旁系同源物的昆虫核心基因家族，我们检测到果蝇（689个）中谱系特异性复制的数量明显高于按蚊（315个）、赤拟谷盗（386个）和蜜蜂（223个）。基于对序列分歧、系统发育分布和基因本体信息的分析，我们提供的证据表明，在高等双翅目（短角亚目）的多样化过程中，基因复制积累的背景速率增加起到了特殊作用，部分原因是为位点内性冲突的解决提供了丰富的机会，这可能在高度多样化的短角亚目裂翅亚科早期辐射期间提高了物种形成速率。
