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川崎样综合征作为年轻人感染新型冠状病毒的一种新出现的并发症

Kawasaki-like Syndrome as an Emerging Complication of SARS-CoV-2 Infection in Young Adults.

作者信息

Burgi Vieira César, Ferreira Ana Teresa, Botelho Cardoso Filipa, Pelicano Paulos Jorge, Germano Nuno

机构信息

Unidade Funcional Medicina 2.4, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal.

Unidade Funcional Medicina 4, Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal.

出版信息

Eur J Case Rep Intern Med. 2020 Sep 10;7(10):001886. doi: 10.12890/2020_001886. eCollection 2020.

Abstract

BACKGROUND

Kawasaki-like syndrome occurring in children during the COVID-19 pandemic has been labelled multisystem inflammatory syndrome in children (MIS-C) by the CDC and paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS) by the ECDC.

CASE REPORT

We report the case of an 18-year-old male patient presenting with a 72-hour history of abdominal pain, fever, erythematous skin rash, vomiting and diarrhoea. Examination showed he also had shock and he was first thought to have oedematous cholecystitis. SARS-CoV-2 infection was also diagnosed. He was admitted to the ICU, and echocardiography showed cardiac dysfunction, with a low ejection fraction and low cardiac index. High-sensitivity troponin serum levels were elevated. The patient received inotropic and vasopressor support. As he fulfilled several criteria for MIS-C/PIMS-TS, he was administered acetylsalicylic acid, corticosteroids and immunoglobulin, with a good clinical response.

CONCLUSION

This case emphasizes how this severe presentation of COVID-19 can easily be misdiagnosed if the clinician is less aware of this syndrome in younger patients.

LEARNING POINTS

SARS-CoV-2 infection is a diagnostic challenge in some patients with atypical clinical presentations, who may have MIS-C/PIMS-TS.Physicians should be aware of this condition when evaluating teenagers and young adults with COVID-19.

摘要

背景

在新冠疫情期间儿童出现的川崎样综合征被美国疾病控制与预防中心(CDC)称为儿童多系统炎症综合征(MIS-C),被欧洲疾病预防与控制中心(ECDC)称为与SARS-CoV-2感染时间相关的儿童炎症性多系统综合征(PIMS-TS)。

病例报告

我们报告一例18岁男性患者,有72小时腹痛、发热、皮肤红斑疹、呕吐和腹泻病史。检查发现他还存在休克,最初被认为患有水肿性胆囊炎。同时也诊断出SARS-CoV-2感染。他被收入重症监护病房(ICU),超声心动图显示心脏功能障碍,射血分数低和心脏指数低。高敏肌钙蛋白血清水平升高。患者接受了强心和血管加压支持治疗。由于他符合MIS-C/PIMS-TS的多项标准,给予了阿司匹林、皮质类固醇和免疫球蛋白治疗,临床反应良好。

结论

该病例强调,如果临床医生对年轻患者中的这种综合征认识不足,新冠病毒感染的这种严重表现很容易被误诊。

经验教训

SARS-CoV-2感染对一些临床表现不典型的患者是一个诊断挑战,这些患者可能患有MIS-C/PIMS-TS。医生在评估患有新冠病毒感染的青少年和年轻人时应意识到这种情况。

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本文引用的文献

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COVID-19 and Kawasaki syndrome: should we really be surprised?新冠病毒与川崎病:我们真的应该感到惊讶吗?
Cardiol Young. 2020 Jul;30(7):1059-1060. doi: 10.1017/S1047951120001432. Epub 2020 Jun 25.
2
Reality of Kawasaki disease epidemiology.川崎病流行病学的实际情况。
Korean J Pediatr. 2019 Aug;62(8):292-296. doi: 10.3345/kjp.2019.00157. Epub 2019 Jul 9.

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