VanArsdale Eric, Pitzer Juliana, Payne Gregory F, Bentley William E
Fischell Department of Bioengineering, University of Maryland, 3102 A. James Clark Hall 8278 Paint Branch Drive, College Park, MD 20742, USA.
Institute of Bioscience and Biotechnology Research, University of Maryland, 5115 Plant Sciences Building, College Park, MD 20742, USA.
iScience. 2020 Sep 8;23(9):101545. doi: 10.1016/j.isci.2020.101545. eCollection 2020 Sep 25.
Cells often communicate by the secretion, transport, and perception of molecules. Information conveyed by molecules is encoded, transmitted, and decoded by cells within the context of the prevailing microenvironments. Conversely, in electronics, transmission reliability and message validation are predictable, robust, and less context dependent. In turn, many transformative advances have resulted by the formal consideration of information transfer. One way to explore this potential for biological systems is to create bio-device interfaces that facilitate bidirectional information transfer between biology and electronics. Redox reactions enable this linkage because reduction and oxidation mediate communication within biology and can be coupled with electronics. By manipulating redox reactions, one is able to combine the programmable features of electronics with the ability to interrogate and modulate biological function. In this review, we examine methods to electrochemically interrogate the various components of molecular communication using redox chemistry and to electronically control cell communication using redox electrogenetics.
细胞常常通过分子的分泌、运输和感知来进行通讯。分子所传递的信息在当前微环境的背景下由细胞进行编码、传输和解码。相反，在电子学中，传输可靠性和信息验证是可预测的、稳健的，且较少依赖上下文。相应地，通过对信息传递的正式考量已经带来了许多变革性进展。探索生物系统这种潜力的一种方法是创建生物-设备接口，以促进生物学与电子学之间的双向信息传递。氧化还原反应实现了这种联系，因为还原和氧化介导了生物体内的通讯，并且可以与电子学相结合。通过操纵氧化还原反应，人们能够将电子学的可编程特性与询问和调节生物功能的能力结合起来。在本综述中，我们研究了利用氧化还原化学以电化学方式询问分子通讯的各个组件，以及利用氧化还原电遗传学以电子方式控制细胞通讯的方法。
