Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Hospital of the Universities of Giessen and Marburg UKGM, Justus Liebig University Giessen, Feulgenstr 12, 35440, Giessen, Germany.
J Neurol. 2021 Dec;268(12):4587-4593. doi: 10.1007/s00415-020-10275-x. Epub 2020 Oct 20.
Multiple sclerosis (MS) is a complex autoimmune disorder characterized by neurologic dysfunction. The symptoms worsen as the disease progresses to the relapsing stage.
This study aimed to examine the role of T cells in MS pathogenesis.
The review was performed based on articles obtained from PsycINFO, PubMed, Web of Science, and CINAHL. Search terms and phrases, such as "multiple sclerosis," "MS," "T cells," "development," "Dysregulated T cells," and "Effector T cells", were used to identify articles that could help explore the research topic.
The pathogenesis of MS is linked to the regulatory, inflammatory, suppressive, and effector roles of T cells. However, the actual roles of specific T cell subsets in MS development are not well understood.
The study revealed a significant link between MS and T cell activity. Targeting T cells is a potential strategy for the development of new therapies to manage MS.
MS is a complex demyelinating condition that affects several million people around the world. Research has revealed that various classes of T cells, including effector T cells and regulatory T cells, influence the development and progression of MS. Further investigations are required to elucidate the underlying mechanisms through which specific T cell populations influence MS pathogenesis.
多发性硬化症（MS）是一种复杂的自身免疫性疾病，其特征是神经功能障碍。随着疾病进展到复发阶段，症状会恶化。
本研究旨在探讨 T 细胞在多发性硬化症发病机制中的作用。
综述基于从 PsycINFO、PubMed、Web of Science 和 CINAHL 获得的文章进行。使用了诸如“多发性硬化症”、“MS”、“T 细胞”、“发育”、“失调的 T 细胞”和“效应 T 细胞”等搜索词和短语，以确定可以帮助探索研究主题的文章。
MS 的发病机制与 T 细胞的调节、炎症、抑制和效应作用有关。然而，特定 T 细胞亚群在 MS 发展中的实际作用尚不清楚。
该研究揭示了 MS 与 T 细胞活性之间的显著联系。靶向 T 细胞是开发新疗法以管理 MS 的潜在策略。
MS 是一种影响全球数百万人的复杂脱髓鞘疾病。研究表明，各种 T 细胞类群，包括效应 T 细胞和调节性 T 细胞，影响 MS 的发展和进展。需要进一步研究阐明特定 T 细胞群体如何影响 MS 发病机制的潜在机制。
