Institute of Physiologically Active Compounds of the Russian Academy of Sciences, 142432, Chernogolovka, Moscow oblast, Russia.
Research Center for Biomedical Technologies, Federal Biomedical Agency of Russia, 143442, Moscow, Russia.
Dokl Biol Sci. 2020 Sep;494(1):225-227. doi: 10.1134/S0012496620050026. Epub 2020 Oct 20.
The present study demonstrates the effect of combined ionizing radiation (γ rays, 0.24 Gy, 661.7 keV, whole body and C, 0.18 Gy, 450 MeV, head region) on the behavior of animals in mouse transgenic models of Alzheimer's disease. Significant improvement of spatial learning and stimulation of locomotor and exploratory behavior were observed in wild-type mice after irradiation. However, an anxiolytic effect and stimulation of locomotor and exploratory behavior were revealed in irradiated mice with tauopathy. Mice with cerebral amyloidosis also exhibited improved learning in the odor recognition test. No negative effects of irradiation were detected.
本研究证明了联合电离辐射（γ射线，0.24 Gy，661.7 keV，全身和 C 射线，0.18 Gy，450 MeV，头部区域）对阿尔茨海默病转基因动物模型中动物行为的影响。在照射后，野生型小鼠的空间学习能力显著提高，运动和探索行为也得到刺激。然而，在患有 tau 病变的照射小鼠中，观察到了抗焦虑作用以及运动和探索行为的刺激。脑淀粉样蛋白病小鼠在嗅觉识别测试中也表现出学习能力的提高。未检测到照射的负面影响。
