通过二氟烯氧硅烷与 MBH 碳酸酯的烯丙基烷基化反应合成多功能α,α-二氟酮。
Synthesis of Multifunctional α,α-Difluoroketones through Allylic Alkylation of Difluoroenoxysilanes with MBH Carbonates.
机构信息
College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, P. R. China.
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, East China Normal University, Shanghai, 200062, P. R. China.
出版信息
Chem Asian J. 2020 Dec 1;15(23):4028-4032. doi: 10.1002/asia.202001145. Epub 2020 Nov 4.
The first allylic alkylation of difluoroenoxysilanes with MBH carbonates catalyzed by triethylenediamine (DABCO) is developed, which allows rapid access to multifunctional α-gem-difluoroketones with up to 97% yields. Moreover, the gram-scale synthesis and the diversifying transformation of products to valuable gem-difluorinated molecules highlight the practicality of this methodology.
三乙烯二胺（DABCO）催化二氟烯氧基硅烷与 MBH 碳酸酯的首例烯丙基烷基化反应被开发出来，该反应能够以高达 97%的收率快速得到多功能的α-位全氟代酮。此外，克级规模的合成以及产物向有价值的全氟代分子的多样化转化凸显了该方法的实用性。
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