从. 的菌核中提取的酚类化合物。
Phenolic compounds from the sclerotia of .
机构信息
Hainan Key Laboratory for Research and Development of Natural Products from Li folk Medicine, Institute of Bioscience and Biotechnology, Chinese Academy of Agricultural Sciences, Haikou, P.R. China.
Hainan Institute for Tropical Agricultural Resources, Chinese Academy of Agricultural Sciences, Haikou, P.R. China.
出版信息
Nat Prod Res. 2022 May;36(9):2413-2417. doi: 10.1080/14786419.2020.1833202. Epub 2020 Oct 21.
Three phenolic compounds (± and ) including a pair of new enantiomers were isolated from the sclerotia of . Their structures were assigned by extensive spectroscopic analyses. All the compounds were evaluated for the neuroprotective activity against oxidative damage on human neuroblastoma SH-SY5Y cells induced by HO. Compound showed remarkable neuroprotective effect and significantly improved the cell viability of SH-SY5Y cells treated by HO.
从 的菌核中分离得到了三种酚类化合物（± 和 ），其中包括一对新的对映异构体。通过广泛的光谱分析确定了它们的结构。所有化合物均进行了评估，以研究其对由 HO 诱导的人神经母细胞瘤 SH-SY5Y 细胞氧化损伤的神经保护活性。化合物 表现出显著的神经保护作用，并显著提高了 HO 处理的 SH-SY5Y 细胞的细胞活力。
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