EaStCHEM School of Chemistry, University of Edinburgh, EH9 3FJ, Edinburgh, UK.
Chem Commun (Camb). 2020 Nov 18;56(89):13856-13859. doi: 10.1039/d0cc04591h. Epub 2020 Oct 21.
A polymer scaffold, with multiple reactive centres, was synthesised by RAFT polymerisation and conjugated to the antibody herceptin. A hexahistidine RAFT agent enabled the rapid and simple purification of polymer-protein conjugates, while the tetrazine conjugation strategy allows myriad cargos to be attached and amplified.
通过 RAFT 聚合反应合成了一种具有多个反应中心的聚合物支架，并将其与抗体赫赛汀偶联。六组氨酸 RAFT 试剂可实现聚合物-蛋白质偶联物的快速简单纯化，而四嗪偶联策略则允许无数的有效载荷被连接和放大。
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