Lygidakis N J, Chamuleau R A, Rothuizen J, Grijm R, van Baal J G, Kox K, van Altena E, van Joost H E, van den Brom W E, Jöbsis A C
Department of Surgery, University of Amsterdam, The Netherlands.
Eur Surg Res. 1987;19(5):265-75. doi: 10.1159/000128709.
Segmental auxiliary liver transplantation (SALT) has been carried out in 13 mongrel dogs to assess the possibility of a certain size of liver segment to accept without sequelae the total splanchnic and arterial blood normally diverted to the liver of the host. Prednisone (1 mg/daily) and azathioprine (2 mg/kg daily) were used as immunosuppression. Five dogs died during the first hours after the operation. Three because of technical failure and two of acute portal hypertension secondary to total portal and arterial blood diversion in dogs with liver segments of 195 +/- 49 g as a result of overloading of the graft. The remaining 8 dogs were divided into: 4 dogs into which a liver segment (195 +/- 49 g) was transplanted (group A) and 4 dogs in which a liver segment (385 +/- 85 g) was used (group B). Partial portal and total arterial blood diversion in group A dogs was not associated with portal hypertension but resulted in poor function of the graft and in poor survival. In contrast, the graft in group B dogs was able to cope with both total or partial portal blood and with a normal arterial blood diversion. Infection and graft rejection prohibited long-term survival (8-28 days). Data from this study support the view that the present technique of SALT with a graft corresponding to 300-400 g in mongrel dogs of about 30 kg is a potential alternative as temporary liver support in the diseased animal.
对13只杂种犬进行了节段性辅助肝移植（SALT），以评估一定大小的肝段能否无后遗症地接纳通常分流至宿主肝脏的全部内脏和动脉血。使用泼尼松（1毫克/日）和硫唑嘌呤（2毫克/千克体重/日）进行免疫抑制。5只犬在术后最初数小时内死亡。3只因技术失败，2只因移植肝段重量为195±49克的犬在门静脉和动脉血完全分流后出现急性门静脉高压。其余8只犬分为：4只移植了肝段（195±49克）的犬（A组）和4只使用了肝段（385±85克）的犬（B组）。A组犬的部分门静脉和全部动脉血分流未导致门静脉高压，但导致移植肝功能不良和存活率低。相比之下，B组犬的移植肝能够应对全部或部分门静脉血以及正常的动脉血分流。感染和移植排斥反应妨碍了长期存活（8 - 28天）。本研究数据支持以下观点：在约30千克的杂种犬中，采用与300 - 400克相对应的移植肝段的当前SALT技术，作为患病动物的临时肝支持是一种潜在的替代方法。
