Functional Genomics Unit, CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, 110007, India.
Academy of Scientific and Innovative Research, (AcSIR), Ghaziabad, 201 002, India.
Cell Mol Life Sci. 2021 Feb;78(4):1405-1421. doi: 10.1007/s00018-020-03670-0. Epub 2020 Oct 21.
Mitochondria are not only important for cellular bioenergetics but also lie at the heart of critical metabolic pathways. They can rapidly adjust themselves in response to changing conditions and the metabolic needs of the cell. Mitochondrial involvement as well as its dysfunction has been found to be associated with variety of pathological processes and diseases. mitomiRs are class of miRNA(s) that regulate mitochondrial gene expression and function. This review sheds light on the role of mitomiRs in regulating different biological processes-mitochondrial dynamics, oxidative stress, cell metabolism, chemoresistance, apoptosis,and their relevance in metabolic diseases, neurodegenerative disorders, and cancer. Insilico analysis of predicted targets of mitomiRs targeting energy metabolism identified several significantly altered pathways (needs in vivo validations) that may provide a new therapeutic approach for the treatment of human diseases. Last part of the review discusses about the clinical aspects of miRNA(s) and mitomiRs in Medicine.
线粒体不仅对细胞生物能量学至关重要，而且也是关键代谢途径的核心。它们可以根据不断变化的条件和细胞的代谢需求迅速自我调整。线粒体的参与及其功能障碍与多种病理过程和疾病有关。mitomiRs 是一类 miRNA，可调节线粒体基因表达和功能。这篇综述阐述了 mitomiRs 在调节不同生物过程中的作用，包括线粒体动力学、氧化应激、细胞代谢、化疗耐药性、细胞凋亡，以及它们在代谢性疾病、神经退行性疾病和癌症中的相关性。对 mitomiRs 靶向能量代谢的预测靶标的计算机分析确定了几个显著改变的途径（需要体内验证），这可能为治疗人类疾病提供新的治疗方法。综述的最后一部分讨论了 miRNA 和 mitomiRs 在医学中的临床方面。
