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在不同温度条件下糖尿病或肥胖小鼠中富含甘油三酯的脂蛋白衍生脂肪酸的棕色脂肪组织摄取情况。

Brown adipose tissue uptake of triglyceride-rich lipoprotein-derived fatty acids in diabetic or obese mice under different temperature conditions.

作者信息

Paulus Andreas, Drude Natascha, van Marken Lichtenbelt Wouter, Mottaghy Felix M, Bauwens Matthias

机构信息

Department of Radiology and Nuclear Medicine, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.

Department of Nuclear Medicine, University Hospital RWTH Aachen, Aachen, Germany.

出版信息

EJNMMI Res. 2020 Oct 21;10(1):127. doi: 10.1186/s13550-020-00701-6.

DOI:10.1186/s13550-020-00701-6
PMID:33085016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7578207/
Abstract

BACKGROUND

In vivo imaging of glucose analogue 2-deoxy-2-[F]fluoro-D-glucose ([F]FDG) via positron emission tomography (PET) is the current gold standard to visualize and assess brown adipose tissue (BAT) activity. However, glucose metabolism is only a part of the metabolic activity of BAT. [F]FDG-PET has been shown in clinical trials to often fail to visualize BAT under insulin-resistant conditions associated with aging and weight gain. We employed a novel developed triglyceride-based tracer to visualize BATs metabolic activity under different temperature conditions as well as under diabetic and obese conditions in preclinical models.

RESULTS

[F]BDP-TG-chylomicron-like particles visualized BAT in control, streptozocin-induced diabetes and obese mice. Increased BAT tracer uptake was found in control mice acutely exposed to cold but not in cold-acclimated animals. Diabetes did not remove BAT tracer uptake, but did limit BAT tracer uptake to levels of control mice housed at 21 °C. In obese animals, BAT tracer uptake was significantly reduced, although the stimulating effect of cold exposure could still be noted.

CONCLUSION

BAT was visualized in control, diabetic and obese conditions. Streptozocin-induced diabetes, but not obesity, inhibited the stimulatory effect of cold exposure.

摘要

背景

通过正电子发射断层扫描（PET）对葡萄糖类似物2-脱氧-2-[F]氟-D-葡萄糖（[F]FDG）进行体内成像，是目前可视化和评估棕色脂肪组织（BAT）活性的金标准。然而，葡萄糖代谢只是BAT代谢活动的一部分。在临床试验中已表明，[F]FDG-PET在与衰老和体重增加相关的胰岛素抵抗条件下，常常无法使BAT可视化。我们采用一种新开发的基于甘油三酯的示踪剂，在临床前模型中，观察不同温度条件以及糖尿病和肥胖条件下BAT的代谢活性。

结果

[F]BDP-TG-乳糜微粒样颗粒在对照、链脲佐菌素诱导的糖尿病和肥胖小鼠中使BAT可视化。在急性暴露于寒冷的对照小鼠中发现BAT示踪剂摄取增加，但在冷适应动物中未发现。糖尿病并未消除BAT示踪剂摄取，但确实将BAT示踪剂摄取限制在饲养于21°C的对照小鼠的水平。在肥胖动物中，BAT示踪剂摄取显著降低，尽管仍可注意到冷暴露的刺激作用。

结论

在对照、糖尿病和肥胖条件下均可使BAT可视化。链脲佐菌素诱导的糖尿病而非肥胖抑制了冷暴露的刺激作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7578207/617e3900ebb1/13550_2020_701_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7578207/cf85866eb112/13550_2020_701_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7578207/fb2dc7e55a52/13550_2020_701_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7578207/b9f94ad619fa/13550_2020_701_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7578207/617e3900ebb1/13550_2020_701_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7578207/cf85866eb112/13550_2020_701_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7578207/fb2dc7e55a52/13550_2020_701_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7578207/b9f94ad619fa/13550_2020_701_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c40/7578207/617e3900ebb1/13550_2020_701_Fig4_HTML.jpg

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