Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, Canada J1H 5N4.
Faculty of Health Sciences, University of Ottawa, 125 University Pvt. Ottawa, ON, Canada K1N 6N5.
Nat Commun. 2017 Jan 30;8:14146. doi: 10.1038/ncomms14146.
In rodents, brown adipose tissue (BAT) plays an important role in producing heat to defend against the cold and can metabolize large amounts of dietary fatty acids (DFA). The role of BAT in DFA metabolism in humans is unknown. Here we show that mild cold stimulation (18 °C) results in a significantly greater fractional DFA extraction by BAT relative to skeletal muscle and white adipose tissue in non-cold-acclimated men given a standard liquid meal containing the long-chain fatty acid PET tracer, 14(R,S)-[F]-fluoro-6-thia-heptadecanoic acid (FTHA). However, the net contribution of BAT to systemic DFA clearance is comparatively small. Despite a 4-week cold acclimation increasing BAT oxidative metabolism 2.6-fold, BAT DFA uptake does not increase further. These findings show that cold-stimulated BAT can contribute to the clearance of DFA from circulation but its contribution is not as significant as the heart, liver, skeletal muscles or white adipose tissues.
在啮齿动物中，棕色脂肪组织（BAT）在产生热量以抵御寒冷方面起着重要作用，并且可以代谢大量膳食脂肪酸（DFA）。BAT 在人体中对 DFA 代谢的作用尚不清楚。在这里，我们表明，在给予含有长链脂肪酸 PET 示踪剂 14(R,S)-[F]-氟-6-硫十七烷酸（FTHA）的标准液体餐的非冷适应男性中，温和的冷刺激（18°C）导致 BAT 相对于骨骼肌和白色脂肪组织对 DFA 的分数提取显著增加。然而，BAT 对全身 DFA 清除的净贡献相对较小。尽管 4 周的冷适应使 BAT 的氧化代谢增加了 2.6 倍，但 BAT 对 DFA 的摄取并没有进一步增加。这些发现表明，冷刺激的 BAT 可以有助于从循环中清除 DFA，但它的贡献不如心脏、肝脏、骨骼肌或白色脂肪组织重要。
