McLeod D, Hiscott P S, Grierson I
Surgical Vitreoretinal Unit, Moorfields Eye Hospital, London.
Eye (Lond). 1987;1 ( Pt 2):263-81. doi: 10.1038/eye.1987.46.
Clinical and pathological features of non-vascularised epiretinal membranes are reviewed with special attention to focal epimacular tractional lesions in the elderly. The role of immunohistochemistry in elucidating the nature of component cells of complex epiretinal membranes is emphasised. Clinicopathological correlation establishes the 'fibroglial membrane' as the causative lesion of age-related epimacular traction. The pathogenesis of this process is discussed, including relevant animal models, and chronic inflammation and ischaemia (rather than acute posterior vitreous detachment) are implicated. Vitrectomy and epimacular membrane peeling results in significant visual improvement in most patients.
本文回顾了无血管性视网膜前膜的临床和病理特征，特别关注老年人的黄斑区局灶性牵引性病变。强调了免疫组织化学在阐明复杂视网膜前膜组成细胞性质方面的作用。临床病理相关性确定“纤维胶质膜”是年龄相关性黄斑区牵引的致病病变。讨论了这一过程的发病机制，包括相关动物模型，认为慢性炎症和缺血（而非急性玻璃体后脱离）与之相关。玻璃体切除术和视网膜前膜剥离术可使大多数患者的视力得到显著改善。
