Kwon Yoowon, Jeong Su Jin
Departments of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam 13496, Korea.
J Clin Med. 2020 Oct 19;9(10):3355. doi: 10.3390/jcm9103355.
Recently, sarcopenia was identified as a risk factor for non-alcoholic fatty liver disease (NAFLD) in adults. We here investigated the association between skeletal muscle mass (SMM) and NAFLD in non-obese children and adolescents. A retrospective medical chart review was performed for individuals aged 9-15 years diagnosed with NAFLD. Healthy volunteers aged 9-15 years were recruited as controls. Participants were subject to laboratory tests, abdominal sonography, and multi-frequency bioelectrical impedance analysis. SMM data were calculated as the skeletal muscle-to-body fat ratio (MFR), and the diagnosis of fatty liver was established by abdominal sonography. The control and NAFLD groups included 73 and 53 individuals, respectively. No significant difference was observed in gender and body mass index (BMI) distribution between the groups. Mean MFR was significantly lower in individuals with NAFLD than in those without (0.83 vs. 1.04, = 0.005). After adjusting for age, sex, BMI, and serum glucose, the risk of having NAFLD was significantly associated with a decreased MFR ( = 0.016). NAFLD is significantly associated with relatively low SMM in non-obese children and adolescents. Increasing SMM, such as weight training, can be suggested as one of the treatment strategies in pediatric NAFLD without obesity.
最近，肌肉减少症被确定为成人非酒精性脂肪性肝病（NAFLD）的一个风险因素。我们在此研究了非肥胖儿童和青少年的骨骼肌质量（SMM）与NAFLD之间的关联。对9至15岁被诊断为NAFLD的个体进行了回顾性病历审查。招募9至15岁的健康志愿者作为对照。参与者接受了实验室检查、腹部超声检查和多频生物电阻抗分析。SMM数据计算为骨骼肌与体脂比（MFR），脂肪肝的诊断通过腹部超声检查确定。对照组和NAFLD组分别包括73人和53人。两组之间在性别和体重指数（BMI）分布上未观察到显著差异。NAFLD患者的平均MFR显著低于无NAFLD者（0.83对1.04，P = 0.005）。在调整年龄、性别、BMI和血糖后，患NAFLD的风险与MFR降低显著相关（P = 0.016）。在非肥胖儿童和青少年中，NAFLD与相对较低的SMM显著相关。增加SMM，如进行重量训练，可以作为非肥胖型儿童NAFLD治疗策略之一。
