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一项关于希腊主要 HIV-1 亚型 A1 和 B 传播模式的全国性研究：分子传播集群的推断。

A Nationwide Study about the Dispersal Patterns of the Predominant HIV-1 Subtypes A1 and B in Greece: Inference of the Molecular Transmission Clusters.

机构信息

Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

1st Department of Internal Medicine, G. Gennimatas General Hospital, 11527 Athens, Greece.

出版信息

Viruses. 2020 Oct 19;12(10):1183. doi: 10.3390/v12101183.

DOI:
10.3390/v12101183
PMID:33086773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7589601/
Abstract

Our aim was to investigate the dispersal patterns and parameters associated with local molecular transmission clusters (MTCs) of subtypes A1 and B in Greece (predominant HIV-1 subtypes). The analysis focused on 1751 (28.4%) and 2575 (41.8%) sequences of subtype A1 and B, respectively. Identification of MTCs was based on phylogenetic analysis. The analyses identified 38 MTCs including 2-1518 subtype A1 sequences and 168 MTCs in the range of 2-218 subtype B sequences. The proportion of sequences within MTCs was 93.8% (1642/1751) and 77.0% (1982/2575) for subtype A1 and B, respectively. Transmissions within MTCs for subtype A1 were associated with risk group (Men having Sex with Men vs. heterosexuals, OR = 5.34, < 0.001) and Greek origin (Greek vs. non-Greek origin, OR = 6.05, < 0.001) and for subtype B, they were associated with Greek origin (Greek vs. non-Greek origin, OR = 1.57, = 0.019), younger age (OR = 0.96, < 0.001), and more recent sampling (time period: 2011-2015 vs. 1999-2005, OR = 3.83, < 0.001). Our findings about the patterns of across and within country dispersal as well as the parameters associated with transmission within MTCs provide a framework for the application of the study of molecular clusters for HIV prevention.

摘要

我们的目的是调查在希腊（主要的 HIV-1 亚型）中与亚型 A1 和 B 的局部分子传播簇（MTC）相关的传播模式和参数。该分析集中在分别为 1751（28.4%）和 2575（41.8%）的亚型 A1 和 B 序列上。MTC 的识别基于系统发生分析。分析确定了 38 个 MTC，包括 2-1518 个亚型 A1 序列和 168 个 MTC，范围在 2-218 个亚型 B 序列内。MTC 内序列的比例分别为 93.8%（1642/1751）和 77.0%（1982/2575），用于亚型 A1 和 B。MTC 内的传播与风险群体（男男性行为者与异性恋者相比，OR = 5.34，<0.001）和希腊血统（希腊与非希腊血统相比，OR = 6.05，<0.001）有关对于亚型 B，它们与希腊血统（希腊与非希腊血统相比，OR = 1.57，= 0.019）、年龄较小（OR = 0.96，<0.001）和最近的采样（时间段：2011-2015 年与 1999-2005 年相比，OR = 3.83，<0.001）有关。我们关于跨国和国内传播模式以及与 MTC 内传播相关的参数的发现为应用分子簇研究 HIV 预防提供了框架。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2490/7589601/ccd79db0fa51/viruses-12-01183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2490/7589601/5890d5576a10/viruses-12-01183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2490/7589601/e1285879163f/viruses-12-01183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2490/7589601/ccd79db0fa51/viruses-12-01183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2490/7589601/5890d5576a10/viruses-12-01183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2490/7589601/e1285879163f/viruses-12-01183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2490/7589601/ccd79db0fa51/viruses-12-01183-g003.jpg

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