Clark C V, Mapstone R
Glaucoma Unit, St. Paul's Eye Hospital, Liverpool, United Kingdom.
Invest Ophthalmol Vis Sci. 1987 Oct;28(10):1732-5.
Seventy-eight ocular hypertensive patients and 47 age-and sex-matched control subjects were assessed for parasympathetic denervation hypersensitivity of the iris using topical application of 2.5% methacholine chloride solution. Constriction of the pupil in response to methacholine stimulation of the sphincter pupillae was significantly greater in the ocular hypertensive patients than the control group (P less than 0.001). The implications are discussed, with particular reference to the association between autonomic neuropathy and the primary glaucomas.
78例高眼压患者和47例年龄及性别匹配的对照受试者，通过局部应用2.5%氯化乙酰甲胆碱溶液评估虹膜的副交感神经去神经超敏反应。高眼压患者中，对乙酰甲胆碱刺激瞳孔括约肌引起的瞳孔收缩反应显著大于对照组（P<0.001）。文中讨论了其意义，特别提及自主神经病变与原发性青光眼之间的关联。
