Academic Unit of Surgery, School of Medicine, University of Glasgow, Glasgow Royal Infirmary, New Lister Building, Glasgow, G4 0SF, UK.
Sci Rep. 2020 Oct 21;10(1):17965. doi: 10.1038/s41598-020-73909-0.
The aim of this study was to directly compare the prognostic value of cumulative scores and composite ratios in patients with operable rectal cancer. Within a single surgical unit preoperative differential blood cell results including neutrophil (N), lymphocyte (L), monocyte (M) and platelet (P) counts, as well as CRP (C) and albumin (A) levels were recorded. These results were used to construct a series of composite ratios (NLR, PLR, LMR, CAR) and cumulative scores (NLS, PLS, LMS, NPS, mGPS). The relationship between composite ratios and the cumulative scores and clinicopathological characteristics, cancer specific survival (CSS) and overall survival (OS) were examined. A total of 413 patients were included. When adjusted for TNM stage, surgical approach, time of surgery and margin involvement mGPS (p < 0.05) was associated with CSS. In addition, most composite ratios/scores showed correlations with neoadjuvant therapy (p < 0.001). When a direct comparison between NPS (myeloid) and mGPS (liver) was carried out they showed similar associations with both CSS and OS. Therefore, both composite ratios and cumulative scores have been shown to be prognostic in patients with operable rectal cancer.
本研究旨在直接比较可手术直肠癌患者累积评分和综合比值的预后价值。在单个外科单元中，记录了术前差异血液细胞结果，包括中性粒细胞（N）、淋巴细胞（L）、单核细胞（M）和血小板（P）计数，以及 CRP（C）和白蛋白（A）水平。这些结果被用来构建一系列综合比值（NLR、PLR、LMR、CAR）和累积评分（NLS、PLS、LMS、NPS、mGPS）。检查了综合比值和累积评分与临床病理特征、癌症特异性生存（CSS）和总生存（OS）之间的关系。共纳入 413 例患者。当调整 TNM 分期、手术方式、手术时间和边缘累及后，mGPS（p<0.05）与 CSS 相关。此外，大多数复合比值/评分与新辅助治疗呈相关性（p<0.001）。当对 NPS（髓系）和 mGPS（肝脏）进行直接比较时，它们与 CSS 和 OS 均具有相似的相关性。因此，综合比值和累积评分均显示出对可手术直肠癌患者的预后价值。
