噬菌体λ对宿主细胞裂解的遗传与生理控制
Genetic and physiological control of host cell lysis by bacteriophage lambda.
作者信息
Rolfe B G, Campbell J H
出版信息
J Virol. 1977 Sep;23(3):626-36. doi: 10.1128/JVI.23.3.626-636.1977.
Abstract
The timing of host cell lysis at the end of the lytic cycle of phage lambda is under complex control. The lambda S protein stimulates lysis. Another physiological system, the lysis regulator, inhibitis lysis from occurring prematurely. The effects of a series of phage and bacterial mutations on these controls are described. They show that the lambda rex gene plays a role in regulating lysis under suboptimal growth conditions. In certain mutant cells, and especially under anaerobic culture conditions, the rex gene aids in the scheduling of host cell lysis. The data also suggest that the lysis regulator may control the transition of the lambda S protein from an inactive to an active state.
摘要
噬菌体λ裂解周期末期宿主细胞裂解的时间受到复杂的调控。λ S蛋白刺激裂解。另一个生理系统，即裂解调节因子，可抑制裂解过早发生。本文描述了一系列噬菌体和细菌突变对这些调控的影响。结果表明，λ rex基因在次优生长条件下对裂解的调控中发挥作用。在某些突变细胞中，尤其是在厌氧培养条件下，rex基因有助于安排宿主细胞的裂解时间。数据还表明，裂解调节因子可能控制着λ S蛋白从无活性状态到活性状态的转变。
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