Tavakoli Tahmine, Hoseini Masoud, Tabatabaee Toktam Sadat Jafar, Rostami Zeinab, Mollaei Homa, Bahrami Afsane, Ayati Sara, Bijari Bita
Department of Gastroenterology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Birjand Science and Research Branch, Islamic Azad University, Birjand, Iran.
J Res Med Sci. 2020 Jun 30;25:59. doi: 10.4103/jrms.JRMS_673_19. eCollection 2020.
Functional dyspepsia is a common chronic digestive disorder. The purpose of this study was to compare the effectiveness of dialectical behavior therapy and anti-anxiety medication in patients with functional dyspepsia.
The present study was a randomized, controlled clinical trial with sixty patients who were suffering from functional dyspepsia that identified by the ROME III criteria. Patients were divided into three groups by using pre- and posttest design, including Group A (dialectal treatment and pantoprazole), Group B (anxiolytic drug treatment and pantoprazole), and Group C (no intervention, only pantoprazole were used). The Beck Anxiety Inventory and the patient assessment of Gastrointestinal Symptom Severity Index Questionnaire were completed by the patients after receiving the written consent. Finally, the data were analyzed using the Statistical Package for the Social Sciences software version 20.
There was a significant improvement in the severity of dyspepsia after intervention in all three groups. The greatest decrease in the severity of functional dyspepsia was observed in the dialectical behavioral therapy group as compared to the other groups (Group A: -15.4 ± 6.61, Group B: -3.85 ± 2.77, and Group C: -7.8 ± 4.02; = 0.001). Furthermore, the Beck Anxiety Inventory scores were statistically significantly improved in all three groups (Group A: -5.75 ± 2.53, Group B: -7.3 ± 3.19, and Group C: -2.60 ± 1.5; = 0.001). There was a positive correlation between the change in dyspepsia score and change in anxiety score across different intervention groups ( = 0.55; < 0.001).
Dialectical behavioral therapy can be effective in reducing anxiety and improving the dyspepsia symptoms in patients with functional dyspepsia compared to anti-anxiety medication or conventional therapy. Therefore, communication between the physicians and psychologists and psychiatrists can have positive effects on the treatment of these patients.
功能性消化不良是一种常见的慢性消化系统疾病。本研究的目的是比较辩证行为疗法和抗焦虑药物对功能性消化不良患者的疗效。
本研究是一项随机对照临床试验，纳入了60例符合罗马III标准的功能性消化不良患者。采用前后测设计将患者分为三组，包括A组（辩证治疗加泮托拉唑）、B组（抗焦虑药物治疗加泮托拉唑）和C组（不干预，仅使用泮托拉唑）。患者在签署书面知情同意书后完成贝克焦虑量表和胃肠道症状严重程度指数问卷的患者评估。最后，使用社会科学统计软件包20版对数据进行分析。
三组干预后消化不良严重程度均有显著改善。与其他组相比，辩证行为疗法组功能性消化不良严重程度下降最大（A组：-15.4±6.61，B组：-3.85±2.77，C组：-7.8±4.02；P=0.001）。此外，三组的贝克焦虑量表评分在统计学上均有显著改善（A组：-5.75±2.53，B组：-7.3±3.19，C组：-2.60±1.5；P=0.001）。不同干预组消化不良评分变化与焦虑评分变化之间存在正相关（r=0.55；P<0.001）。
与抗焦虑药物或传统疗法相比，辩证行为疗法可有效减轻功能性消化不良患者的焦虑并改善消化不良症状。因此，医生与心理学家和精神科医生之间的沟通对这些患者的治疗可产生积极影响。
