Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
World J Gastroenterol. 2013 Aug 28;19(32):5357-64. doi: 10.3748/wjg.v19.i32.5357.
To study the evolution of gastrointestinal symptoms and associated factors in Chinese patients with functional dyspepsia (FD).
From June 2008 to November 2009, a total of 1049 patients with FD (65.3% female, mean age 42.80 ± 11.64 years) who visited the departments of gastroenterology in Wuhan, Beijing, Shanghai, Guangzhou, and Xi'an, China were referred for this study. All of the patients fulfilled the Rome III criteria for FD. Baseline demographic data, dyspepsia symptoms, anxiety, depression, sleep disorder, and drug treatment were assessed using self-report questionnaires. Patients completed questionnaires at baseline and after 1, 3, 6 and 12 mo follow-up. Comparison of dyspepsia symptoms between baseline and after follow-up was explored using multivariate analysis of variance of repeated measuring. Multiple linear regression was done to examine factors associated with outcome, both longitudinally and horizontally.
Nine hundred and forty-three patients (89.9% of the original population) completed all four follow-ups. The average duration of follow-up was 12.24 ± 0.59 mo. During 1-year follow-up, the mean dyspeptic symptom score (DSS) in FD patients showed a significant gradually reduced trend (P < 0.001), and similar differences were found for all individual symptoms (P < 0.001). Multiple linear regression analysis showed that sex (P < 0.001), anxiety (P = 0.018), sleep disorder at 1-year follow-up (P = 0.019), weight loss (P < 0.001), consulting a physician (P < 0.001), and prokinetic use during 1-year follow-up (P = 0.035) were horizontally associated with DSS at 1-year follow-up. No relationship was found longitudinally between DSS at 1-year follow-up and patient characteristics at baseline.
Female sex, anxiety, and sleep disorder, weight loss, consulting a physician and prokinetic use during 1-year follow-up were associated with outcome of FD.
研究中国功能性消化不良（FD）患者胃肠道症状的演变及其相关因素。
2008 年 6 月至 2009 年 11 月，来自中国武汉、北京、上海、广州和西安的消化内科共 1049 例 FD 患者（65.3%为女性，平均年龄 42.80±11.64 岁）被纳入研究。所有患者均符合罗马 III 诊断 FD 的标准。使用自填式问卷评估基线时的人口统计学数据、消化不良症状、焦虑、抑郁、睡眠障碍和药物治疗情况。患者在基线时以及随访 1、3、6 和 12 个月时完成问卷。使用重复测量方差分析比较基线和随访后消化不良症状的差异。使用多元线性回归分析分别在纵向和横向观察与结局相关的因素。
943 例患者（原始人群的 89.9%）完成了所有 4 次随访。平均随访时间为 12.24±0.59 个月。在 1 年随访期间，FD 患者的平均消化不良症状评分（DSS）呈显著逐渐降低趋势（P＜0.001），且所有单项症状均存在类似差异（P＜0.001）。多元线性回归分析显示，性别（P＜0.001）、焦虑（P=0.018）、1 年随访时的睡眠障碍（P=0.019）、体重减轻（P＜0.001）、就诊（P＜0.001）和 1 年随访时使用促动力药（P=0.035）与 1 年随访时的 DSS 呈横向相关。1 年随访时的 DSS 与基线时的患者特征之间未发现纵向关系。
女性、焦虑和睡眠障碍、体重减轻、就诊和 1 年随访时使用促动力药与 FD 的结局相关。
