Hagan K F, Coffey D S
J Urol. 1977 Aug;118(2):269-73. doi: 10.1016/s0022-5347(17)57971-9.
The 119 non-splinted vasovasostomies that were performed on 95 rats demonstrated that sperm granulomas were present in 99 per cent of the 49 anastomoses that failed. Anastomoses performed on vasa that contained no sperm resulted in 95 per cent patency without granulomas. This procedure was accomplished in immature animals followed to adulthood or by testosterone suppression of spermatogenesis in adult rats. Alternatively, normal adults with sperm in the vasa were irrigated with normal saline at the time of vasovasostomy and this resulted in decreased numbers of granuloma and dramatically improved success rates. Sperm granuloma formation appears to be an important cause of failure of vasovasostomy in the rat.
对95只大鼠进行的119例未用夹板固定的输精管吻合术表明，在49例失败的吻合术中，99%出现了精子肉芽肿。在不含精子的输精管上进行吻合术，通畅率为95%，且无肉芽肿形成。该操作可在未成熟动物中进行并追踪至成年，或通过抑制成年大鼠的精子生成来实现。另外，对输精管中有精子的正常成年大鼠在输精管吻合术时用生理盐水冲洗，这导致肉芽肿数量减少，成功率显著提高。精子肉芽肿的形成似乎是大鼠输精管吻合术失败的一个重要原因。
