用于生物打印的胶原蛋白生物墨水：综述
Collagen as Bioink for Bioprinting: A Comprehensive Review.
作者信息
Osidak Egor Olegovich, Kozhukhov Vadim Igorevich, Osidak Mariya Sergeevna, Domogatsky Sergey Petrovich
机构信息
Imtek Ltd., 3 Cherepkovskaya 15A, Moscow, Russia.
Gamaleya Research Institute of Epidemiology and Microbiology Federal State Budgetary Institution, Ministry of Health of the Russian Federation, Gamalei 18, Moscow, Russia.
出版信息
Int J Bioprint. 2020 Apr 21;6(3):270. doi: 10.18063/ijb.v6i3.270. eCollection 2020.
Abstract
Biomaterials made using collagen are successfully used as a three-dimensional (3D) substrate for cell culture and considered to be promising scaffolds for creating artificial tissues. An important task that arises for engineering such materials is the simulation of physical and morphological properties of tissues, which must be restored or replaced. Modern additive technologies, including 3D bioprinting, can be applied to successfully solve this task. This review provides the latest evidence on advances of 3D bioprinting with collagen in the field of tissue engineering. It contains modern approaches for printing pure collagen bioinks consisting only of collagen and cells, as well as the obtained results from the use of pure collagen bioinks in different fields of tissue engineering.
摘要
使用胶原蛋白制成的生物材料已成功用作细胞培养的三维（3D）基质，并被认为是用于创建人造组织的有前景的支架。对于此类材料的工程设计而言，一项重要任务是模拟必须恢复或替换的组织的物理和形态特性。包括3D生物打印在内的现代增材技术可用于成功解决此任务。本综述提供了有关胶原蛋白3D生物打印在组织工程领域进展的最新证据。它包含用于打印仅由胶原蛋白和细胞组成的纯胶原蛋白生物墨水的现代方法，以及在组织工程不同领域使用纯胶原蛋白生物墨水所获得的结果。
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