Alberts Adina, Bratu Andreea Gabriela, Niculescu Adelina-Gabriela, Grumezescu Alexandru Mihai
Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, Gh. Polizu St. 1-7, 060042 Bucharest, Romania.
Gels. 2025 Apr 5;11(4):271. doi: 10.3390/gels11040271.
Collagen-based wound dressings have developed as an essential component of contemporary wound care, utilizing collagen's inherent properties to promote healing. This review thoroughly analyzes collagen dressing advances, examining different formulations such as hydrogels, films, and foams that enhance wound care. The important processes by which collagen promotes healing (e.g., promoting angiogenesis, encouraging cell proliferation, and offering structural support) are discussed to clarify its function in tissue regeneration. The effectiveness and adaptability of collagen dressings are demonstrated via clinical applications investigated in acute and chronic wounds. Additionally, commercially accessible collagen-based skin healing treatments are discussed, demonstrating their practical use in healthcare settings. Despite the progress, the study discusses the obstacles and restrictions encountered in producing and adopting collagen-based dressings, such as the difficulties of manufacturing and financial concerns. Finally, the current landscape's insights indicate future research possibilities for collagen dressing optimization, bioactive agent integration, and overcoming existing constraints. This analysis highlights the potential of collagen-based innovations to improve wound treatment methods and patient care.
基于胶原蛋白的伤口敷料已发展成为当代伤口护理的重要组成部分，利用胶原蛋白的固有特性促进愈合。本综述全面分析了胶原蛋白敷料的进展，研究了水凝胶、薄膜和泡沫等不同配方，这些配方可增强伤口护理效果。文中讨论了胶原蛋白促进愈合的重要过程（如促进血管生成、刺激细胞增殖和提供结构支持），以阐明其在组织再生中的作用。通过对急性和慢性伤口的临床应用研究，证明了胶原蛋白敷料的有效性和适应性。此外，还讨论了市面上可买到的基于胶原蛋白的皮肤愈合治疗方法，展示了它们在医疗环境中的实际应用。尽管取得了进展，但该研究讨论了在生产和采用基于胶原蛋白的敷料时遇到的障碍和限制，如制造困难和资金问题。最后，对当前形势的洞察指出了胶原蛋白敷料优化、生物活性剂整合以及克服现有限制的未来研究可能性。这一分析突出了基于胶原蛋白的创新在改善伤口治疗方法和患者护理方面的潜力。
