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用牛磺罗定腹膜透析导管封管治疗复发性腹膜透析腹膜炎。

Taurolidine Peritoneal Dialysis Catheter Lock to Treat Relapsing Peritoneal Dialysis Peritonitis.

作者信息

Alvarez Nadal Marta, Sosa Barrios R Haridian, Burguera Vion Víctor, Campillo Trapero Cristina, Fernández Lucas Milagros, Rivera Gorrín Maite E

机构信息

Servicio de Nefrología. Hospital Universitario Ramón y Cajal, Madrid, Spain.

Grupo de Nefrología Diagnóstica e Intervencionista _(GNDI) de la Sociedad Española de Nefrología, Madrid, Spain.

出版信息

Kidney Med. 2020 Jul 13;2(5):650-651. doi: 10.1016/j.xkme.2020.04.012. eCollection 2020 Sep-Oct.

Abstract

Peritonitis remains a primary challenge for the long-term success of peritoneal dialysis (PD) technique and one of the main reasons for catheter removal. Prevention and treatment of catheter-related infections are major concerns to avoid peritonitis. The use of taurolidine catheter-locking solution to avoid the development of a biofilm in the catheter's lumen has obtained good results in hemodialysis catheters for reducing infection rates, although there is scarce literature available regarding its utility in PD. We describe the case of a woman in her 60s who developed relapsing peritonitis due to , with no possibility of removing peritoneal dialysis catheter because she was not a suitable candidate for hemodialysis. After the fourth peritonitis episode caused by species, the use of taurolidine catheter-locking solution was initiated. She received a total of 9 doses, with a favorable microbiological and clinical outcome and no further relapses more than 10 months after taurolidine PD catheter lock treatment was started. We report the successful elimination of an aggressive bacteria after taurolidine PD catheter lock use, with no relevant adverse events.

摘要

腹膜炎仍然是腹膜透析(PD)技术长期成功面临的主要挑战,也是拔除导管的主要原因之一。预防和治疗与导管相关的感染是避免腹膜炎的主要关注点。使用牛磺罗定导管封管溶液以避免在导管腔内形成生物膜,在血液透析导管中已取得良好效果,可降低感染率,尽管关于其在腹膜透析中的应用的文献很少。我们描述了一名60多岁女性的病例,她因[未提及具体病因]发生复发性腹膜炎,由于她不是血液透析的合适候选人,因此无法拔除腹膜透析导管。在由[未提及具体菌种]引起的第四次腹膜炎发作后,开始使用牛磺罗定导管封管溶液。她总共接受了9次给药,微生物学和临床结果良好,在开始牛磺罗定腹膜透析导管封管治疗后10多个月没有进一步复发。我们报告了在使用牛磺罗定腹膜透析导管封管后成功清除侵袭性细菌,且无相关不良事件。

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Antimicrobial activity of a novel catheter lock solution.一种新型导管封管溶液的抗菌活性
Antimicrob Agents Chemother. 2002 Jun;46(6):1674-9. doi: 10.1128/AAC.46.6.1674-1679.2002.

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