Milosavljevic Nina
Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK;
Clocks Sleep. 2019 Jul 12;1(3):319-331. doi: 10.3390/clockssleep1030027. eCollection 2019 Sep.
The idea that light affects mood and behavioral state is not new. However, not much is known about the particular mechanisms and circuits involved. To fully understand these, we need to know what properties of light are important for mediating changes in mood as well as what photoreceptors and pathways are responsible. Increasing evidence from both human and animal studies imply that a specialized class of retinal ganglion cells, intrinsically photosensitive retinal ganglion cells (ipRGCs), plays an important role in the light-regulated effects on mood and behavioral state, which is in line with their well-established roles in other non-visual responses (pupillary light reflex and circadian photoentrainment). This paper reviews our current understanding on the mechanisms and paths by which the light information modulates behavioral state and mood.
光会影响情绪和行为状态这一观点并不新鲜。然而，对于其中涉及的具体机制和神经回路，我们所知甚少。为了全面理解这些，我们需要知道光的哪些特性对于介导情绪变化很重要，以及哪些光感受器和神经通路起作用。来自人类和动物研究的越来越多的证据表明，一类特殊的视网膜神经节细胞，即内在光敏性视网膜神经节细胞（ipRGCs），在光对情绪和行为状态的调节作用中发挥着重要作用，这与其在其他非视觉反应（瞳孔光反射和昼夜节律光同步）中已确立的作用一致。本文综述了我们目前对光信息调节行为状态和情绪的机制及途径的理解。
