Ito Kazuki, Uetsu Masahiro, Kadotani Hiroshi
Department of Sleep and Behavioral Sciences, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan;
Department of Anesthesiology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.
Clocks Sleep. 2020 Aug 29;2(3):364-374. doi: 10.3390/clockssleep2030027. eCollection 2020 Sep.
A large epidemiological study using oximetry to analyze obstructive sleep apnea (OSA) and metabolic comorbidities was performed in Japan; however, reliability and validity of oximetry in the Japanese population remains poorly understood. In this study, oximetry data from the epidemiological study were compared with data from clinically performed polysomnography (PSG) and out-of-center sleep testing (OCST) in epidemiological study participants who later attended our outpatient units. The oxygen desaturation index (ODI) from oximetry showed a moderate positive relationship (correlation coefficient = 0.561, < 0.001) with apnea/hypopnea data from PSG/OCST. The area under the receiver operating characteristic curve showed moderate accuracy of this method in the detection of moderate-to-severe or severe OSA. However, the optimal ODI thresholds to detect moderate-to-severe OSA and severe OSA were the same (ODI > 20.1). Oximetry may be a useful tool for screening moderate-to-severe or severe sleep apnea. However, it may be difficult to set an appropriate threshold to distinguish between moderate and severe sleep apnea by oximetry alone.
日本进行了一项使用血氧测定法分析阻塞性睡眠呼吸暂停（OSA）和代谢合并症的大型流行病学研究；然而，血氧测定法在日本人群中的可靠性和有效性仍知之甚少。在本研究中，将该流行病学研究中的血氧测定数据与后来到我们门诊就诊的流行病学研究参与者的临床多导睡眠图（PSG）和院外睡眠测试（OCST）数据进行了比较。血氧测定法得出的氧饱和度下降指数（ODI）与PSG/OCST的呼吸暂停/低通气数据呈中度正相关（相关系数 = 0.561，<0.001）。受试者工作特征曲线下面积显示该方法在检测中度至重度或重度OSA方面具有中等准确性。然而，检测中度至重度OSA和重度OSA的最佳ODI阈值相同（ODI>20.1）。血氧测定法可能是筛查中度至重度或重度睡眠呼吸暂停的有用工具。然而，仅通过血氧测定法可能难以设定区分中度和重度睡眠呼吸暂停的合适阈值。
