DU Hai-Xia, Wei Chang-Lei, Zhang Hui, Deng Jing, Guo Yi-Qing, Zheng Wei-Ping, Yuan Chang-Qing
Department of Oral Medicine, Affiliated Hospital of Qingdao University. Qingdao 266003, China. E-mail:
Shanghai Kou Qiang Yi Xue. 2020 Aug;29(4):423-426.
To study the relationship between atrophic glossitis and anemia, anemia types and other related factors(oral candida infection, xerostomia) in 124 consecutive cases.
One hundred and twenty-four cases with atrophic glossitis and 53 healthy controls were collected from Qingdao local population. The main indexes including general status, oral examination findings, hemoglobin (Hb), mean red blood cell volume (MCV), vitamin B12, ferritin, folic acid, anemia and anemia type, xerostomia and candida infection were statistically analyzed using SPSS 20.0 software package for Student's t test.
Among 124 cases of glossitis group, 48.39% were found with anemia, 41.94% with xerostomia, 79.03% with Candida infection, 29.03% with Vitamin B12 deficiency, 22.58% with ferritin deficiency, 11.29% with folic acid deficiency. The contents of hemoglobin, ferritin and vitamin B12 in glossitis group were significantly lower than those in the control group(P<0.05), and the number of glossitis patients with anemia, xerostomia and candida infection were significantly higher than those in the control group (P<0.05). There was no significant difference in folic acid content between the two groups(P<0.05).
Occurrence of atrophic glossitis is closely related to anemia, vitamin B12 deficiency, ferritin deficiency, xerostomia, oral candida infection. There is no correlation with folic acid deficiency. Patients with atrophic glossitis accompanied by anemia have a higher proportion of macrocytic anemia.
研究124例连续性病例中萎缩性舌炎与贫血、贫血类型及其他相关因素（口腔念珠菌感染、口干症）之间的关系。
从青岛当地人群中收集124例萎缩性舌炎患者及53例健康对照者。对包括一般状况、口腔检查结果、血红蛋白（Hb）、平均红细胞体积（MCV）、维生素B12、铁蛋白、叶酸、贫血及贫血类型、口干症和念珠菌感染等主要指标，使用SPSS 20.0软件包进行统计学分析，采用Student's t检验。
在124例舌炎组病例中，48.39%发现有贫血，41.94%有口干症,79.03%有念珠菌感染，29.03%有维生素B12缺乏，22.58%有铁蛋白缺乏，11.29%有叶酸缺乏。舌炎组血红蛋白、铁蛋白和维生素B12含量显著低于对照组（P<0.05），舌炎患者中贫血、口干症和念珠菌感染的人数显著高于对照组（P<0.05）。两组叶酸含量无显著差异（P>0.05）。
萎缩性舌炎的发生与贫血、维生素B12缺乏、铁蛋白缺乏口干症、口腔念珠菌感染密切相关。与叶酸缺乏无关。萎缩性舌炎伴贫血患者大细胞性贫血比例较高。
