巨幼细胞贫血、高同型半胱氨酸血症和胃壁细胞抗体阳性在非贫血性萎缩性舌炎患者中的意义。
Hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with normocytosis.
机构信息
Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
出版信息
J Formos Med Assoc. 2020 Jun;119(6):1109-1115. doi: 10.1016/j.jfma.2019.07.020. Epub 2019 Jul 27.
BACKGROUND/PURPOSE: Normocytosis is defined as having the mean corpuscular volume (MCV) between 80 fL and 99.9 fL. This study evaluated whether 944 atrophic glossitis (AG) patients with normocytosis had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 532 healthy control subjects or 1064 AG patients.
METHODS
Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 944 AG patients with normocytosis, 1064 AG patients, and 532 healthy control subjects were measured and compared.
RESULTS
We found that 12.4%, 14.5%, 2.3%, 2.0%, 9.0%, and 25.7% of 944 AG patients with normocytosis had blood hemoglobin (Hb), iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Furthermore, 944 AG patients with normocytosis had significantly higher frequencies of blood Hb, iron, vitamin B12, folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects (all P-values < 0.01). On the contrary, 944 AG patients with normocytosis had significantly lower frequencies of blood Hb and vitamin B12 deficiencies and hyperhomocysteinemia than overall 1064 AG patients (all P-values < 0.05).
CONCLUSION
We conclude that there are significantly higher frequencies of anemia and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in AG patients with normocytosis than in healthy control subjects. On the contrary, AG patients with normocytosis have significantly lower frequencies of blood Hb and vitamin B12 deficiencies and hyperhomocysteinemia than overall AG patients.
背景/目的：正常细胞性贫血的定义为平均红细胞体积（MCV）在 80-99.9 fL 之间。本研究评估了 944 例具有正常细胞性贫血的萎缩性舌炎（AG）患者与 532 例健康对照者或 1064 例 AG 患者相比，贫血、血液营养素缺乏、高同型半胱氨酸血症和血清壁细胞抗体（GPCA）阳性的频率是否显著更高。
方法
测量并比较了 944 例具有正常细胞性贫血的 AG 患者、1064 例 AG 患者和 532 例健康对照者的全血细胞计数、血清铁、维生素 B12、叶酸、同型半胱氨酸和 GPCA 水平。
结果
我们发现，944 例具有正常细胞性贫血的 AG 患者中分别有 12.4%、14.5%、2.3%、2.0%、9.0%和 25.7%存在血血红蛋白（Hb）、铁、维生素 B12 和叶酸缺乏、高同型半胱氨酸血症和血清 GPCA 阳性。此外，与 532 例健康对照者相比，944 例具有正常细胞性贫血的 AG 患者具有更高频率的血 Hb、铁、维生素 B12、叶酸缺乏、高同型半胱氨酸血症和血清 GPCA 阳性（均 P 值<0.01）。相反，与总体 1064 例 AG 患者相比，944 例具有正常细胞性贫血的 AG 患者具有更低频率的血 Hb 和维生素 B12 缺乏和高同型半胱氨酸血症（均 P 值<0.05）。
结论
我们的结论是，与健康对照者相比，具有正常细胞性贫血的 AG 患者具有更高频率的贫血以及血清铁、维生素 B12 和叶酸缺乏、高同型半胱氨酸血症和血清 GPCA 阳性。相反，与总体 AG 患者相比，具有正常细胞性贫血的 AG 患者具有更低频率的血 Hb 和维生素 B12 缺乏和高同型半胱氨酸血症。
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