Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
J Formos Med Assoc. 2020 Jan;119(1 Pt 3):544-552. doi: 10.1016/j.jfma.2019.08.002. Epub 2019 Aug 20.
BACKGROUND/PURPOSE: Our previous study found that 127 of 1064 atrophic glossitis (AG) patients have hyperhomocysteinemia. This study assessed whether the AG patients with hyperhomocysteinemia had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than AG patients without hyperhomocysteinemia or healthy control subjects.
The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 127 AG patients with hyperhomocysteinemia, 937 AG patients without hyperhomocysteinemia, and 532 healthy control subjects were measured and compared.
We found that 127 AG patients with hyperhomocysteinemia had significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies and serum GPCA positivity than 532 healthy control subjects (all P-values < 0.001) and significantly higher frequencies of blood Hb and serum vitamin B12 and folic acid deficiencies and serum GPCA positivity than 937 AG patients without hyperhomocysteinemia (all P-values < 0.001). Moreover, 127 AG patients with hyperhomocysteinemia had significantly higher frequencies of macrocytic anemia and significantly lower frequencies of normocytic anemia than 937 AG patients without hyperhomocysteinemia (both P-values < 0.001). Pernicious anemia (22 cases) was found only in AG patients with hyperhomocysteinemia but not in AG patients without hyperhomocysteinemia.
AG patients with hyperhomocysteinemia had significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, and serum GPCA positivity than healthy control subjects and significantly higher frequencies of anemia, serum vitamin B12 and folic acid deficiencies, and serum GPCA positivity than AG patients without hyperhomocysteinemia.
背景/目的：我们之前的研究发现，在 1064 例萎缩性舌炎（AG）患者中，有 127 例存在高同型半胱氨酸血症。本研究评估了高同型半胱氨酸血症的 AG 患者与无高同型半胱氨酸血症的 AG 患者或健康对照组相比，是否贫血、血液营养素缺乏和血清壁细胞抗体（GPCA）阳性率更高。
检测并比较了 127 例高同型半胱氨酸血症的 AG 患者、937 例无高同型半胱氨酸血症的 AG 患者和 532 例健康对照组的血液血红蛋白（Hb）和血清铁、维生素 B12、叶酸、同型半胱氨酸和 GPCA 水平。
我们发现，与 532 例健康对照组相比，127 例高同型半胱氨酸血症的 AG 患者的血液 Hb 和血清铁、维生素 B12 和叶酸缺乏以及血清 GPCA 阳性率显著更高（所有 P 值均<0.001），且血液 Hb 和血清维生素 B12 和叶酸缺乏以及血清 GPCA 阳性率显著更高（所有 P 值均<0.001）。此外，与 937 例无高同型半胱氨酸血症的 AG 患者相比，127 例高同型半胱氨酸血症的 AG 患者的巨细胞性贫血发生率显著更高，正细胞性贫血发生率显著更低（均 P 值<0.001）。仅在高同型半胱氨酸血症的 AG 患者中发现了恶性贫血（22 例），而在无高同型半胱氨酸血症的 AG 患者中未发现。
与健康对照组相比，高同型半胱氨酸血症的 AG 患者的贫血、血清铁、维生素 B12 和叶酸缺乏以及血清 GPCA 阳性率显著更高，与无高同型半胱氨酸血症的 AG 患者相比，贫血、血清维生素 B12 和叶酸缺乏以及血清 GPCA 阳性率更高。
