Orthopedics. 2021 Jan 1;44(1):e95-e100. doi: 10.3928/01477447-20201009-02. Epub 2020 Oct 22.
This study investigated the effect of bone mineral density (BMD) on the diffusion coefficient (DC) of bone cement in percutaneous vertebroplasty (PVP) and the correlation between the DC and the efficacy after PVP. This was a retrospective study of PVP cases with follow-up longer than 12 months. The cases were assigned to 3 groups according to the BMD: BMD decrease group, osteoporosis group, and severe osteoporosis group. The 3 groups were compared regarding bone cement injection volume (IV), diffusion volume (DV), DC, visual analog scale (VAS) score, Oswestry Disability Index (ODI) score, and vertebral height loss ratio (VHLR). The correlation between DC and BMD, IV, DV, and VHLR was analyzed. The least significant difference test was used for comparison among the 3 groups, and the Pearson correlation coefficient was used for correlation analysis. There were a total of 132 cases, including 34 males and 98 females with a mean age of 76.5±9.6 years. The DV was larger than the IV in each group (P<.05). There was no statistically significant difference in the IV, VAS score, and ODI among the 3 groups (P>.05). However, there were significant differences in the DC and VHLR among the 3 groups (P<.05). Correlation analysis showed that there were significant correlations between BMD and IV (-0.716), BMD and DC (0.754), IV and DV (0.502), and IV and DC (-0.666) (P<.01). Scatter plot showed that the correlation between IV and BMD was r=0.716, R=0.513, and the correlation between DC and BMD was r=0.754, R=0.568. The DV was larger than the IV in PVP, and BMD was closely related to the DC. The higher the BMD, the higher the DC. Short-term follow-up revealed that the DC was inversely proportional to the VHLR. [Orthopedics. 2021;44(1):e95-e100.].
本研究探讨了骨密度（BMD）对经皮椎体成形术（PVP）中骨水泥弥散系数（DC）的影响，以及 DC 与 PVP 后疗效的相关性。这是一项回顾性研究，纳入了随访时间超过 12 个月的 PVP 病例。根据 BMD 将病例分为 3 组：BMD 下降组、骨质疏松组和重度骨质疏松组。比较 3 组的骨水泥注射量（IV）、弥散量（DV）、DC、视觉模拟评分（VAS）、Oswestry 功能障碍指数（ODI）和椎体高度丢失比（VHLR）。分析 DC 与 BMD、IV、DV 和 VHLR 的相关性。采用最小显著差数检验进行 3 组间比较，采用 Pearson 相关系数进行相关性分析。共纳入 132 例患者，男 34 例，女 98 例，平均年龄 76.5±9.6 岁。每组的 DV 均大于 IV（P<.05）。3 组间 IV、VAS 评分和 ODI 差异均无统计学意义（P>.05）。但 3 组间 DC 和 VHLR 差异均有统计学意义（P<.05）。相关性分析显示，BMD 与 IV 呈负相关（-0.716），BMD 与 DC 呈正相关（0.754），IV 与 DV 呈正相关（0.502），IV 与 DC 呈负相关（-0.666）（P<.01）。散点图显示 IV 与 BMD 的相关性 r=0.716，R=0.513，DC 与 BMD 的相关性 r=0.754，R=0.568。PVP 中 DV 大于 IV，BMD 与 DC 密切相关。BMD 越高，DC 越高。短期随访显示，DC 与 VHLR 呈反比。[骨科。2021;44(1):e95-e100.]。
