Department of Internal Medicine, Hazrate-Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran.
Department of Immunology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
IUBMB Life. 2020 Dec;72(12):2563-2571. doi: 10.1002/iub.2398. Epub 2020 Oct 22.
Rheumatoid arthritis (RA) is a chronic autoimmune disease caused by established chronic inflammation. Neopterin levels have extensively been considered as a marker of immune activation during inflammation. In this study, we performed a systematic evaluation and meta-analysis to elucidate the overall relationship between neopterin concentration and RA disease activity. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, a systematic review was conducted using PubMed, Google Scholar, Web of Science, and Scopus from 2000 to August 2020. The Newcastle-Ottawa scale was used to assess the quality of eligible studies. The effect size (ES) and corresponding 95% confidence intervals (CIs) were calculated to evaluate this association. A total of 15 studies out of 98 met our inclusion criteria. The pooled analysis found that patients with RA had high level of neopterin; however, no statistically significant association was found between neopterin levels with high, intermediate, and low diseases activity score (DAS)-28 (ES =11.18, 95% CI: 6.02 to 16.34, and I = 91.8%; and ES = 8.57, 95% CI: 6.41 to 10.37, and I = 99.5%; and ES =12.45, 95% CI: -1.68 to 26.58, and I = 99.0%, respectively). Our results indicated that the neopterin concentration does not seem to have any substantial impact on the RA disease activity.
类风湿关节炎（RA）是一种由已确立的慢性炎症引起的慢性自身免疫性疾病。新蝶呤水平被广泛认为是炎症期间免疫激活的标志物。在这项研究中，我们进行了系统评价和荟萃分析，以阐明新蝶呤浓度与 RA 疾病活动度之间的总体关系。根据系统评价和荟萃分析的首选报告项目（PRISMA）指南，使用 PubMed、Google Scholar、Web of Science 和 Scopus 从 2000 年到 2020 年 8 月进行了系统评价。使用纽卡斯尔-渥太华量表评估合格研究的质量。计算效应大小（ES）和相应的 95%置信区间（CI）来评估这种关联。在 98 项研究中，有 15 项符合我们的纳入标准。荟萃分析发现，RA 患者的新蝶呤水平较高；然而，新蝶呤水平与高、中、低疾病活动评分（DAS）-28 之间没有统计学显著关联（ES=11.18，95%CI：6.02 至 16.34，I=91.8%；ES=8.57，95%CI：6.41 至 10.37，I=99.5%；ES=12.45，95%CI：-1.68 至 26.58，I=99.0%）。我们的结果表明，新蝶呤浓度似乎对 RA 疾病活动度没有任何实质性影响。
