Cortez Ana Paula Bidutte, Fisberg Mauro, de Morais Mauro Batista
Post-Graduate Program in Nutrition, Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP), São Paulo, Brazil.
Division of Pediatric Gastroenterology, Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP), São Paulo, Brazil.
Pediatr Obes. 2021 May;16(5):e12741. doi: 10.1111/ijpo.12741. Epub 2020 Oct 21.
Increased intestinal permeability may be associated with certain disorders, such as obesity and small intestine bacterial overgrowth (SIBO).
This study aimed to investigate intestinal permeability and SIBO in excess weight adolescents.
This cross-sectional study included 67 adolescents with excess weight and 66 normal weight adolescents. Excess weight was defined as a body mass index for age (BMI/age) > +1 SD, which includes having excess body weight and obesity. SIBO was diagnosed by a breath test after the ingestion of lactulose according to the production of hydrogen and methane. Zonulin (haptoglobin) was considered an indicator of intestinal permeability.
Adolescents with excess weight had a higher height/age Z-score (median [25th; 75th percentile]: +0.6 [-0.4; +1.0]) than those in the normal weight group (-0.1 [-0.6; +0.7]; P = .014). Zonulin (mg/mL) in the excess weight (2.3 [1.5; 3.8]) adolescents was higher than that in the normal weight (1.6 [1.0; 2.2]) adolescents (P < .001). SIBO was diagnosed in 23.3% (31/133) of the adolescents. The adolescents with SIBO had a lower (P < .05) BMI/age (+0.6 [-0.6; +1.9]) and height/age (-0.3 [-0.7; +0.3]) than the adolescents without SIBO (+1.3 [+0.1; +2.6] and +0.2 [-0.5; +1.0], respectively). No association was found between zonulin and SIBO.
Excess weight is associated with increased intestinal permeability. No relationship was found between SIBO and intestinal permeability; however, SIBO was related to lower BMI and height for age Z-scores.
肠道通透性增加可能与某些疾病有关，如肥胖和小肠细菌过度生长（SIBO）。
本研究旨在调查超重青少年的肠道通透性和SIBO。
这项横断面研究纳入了67名超重青少年和66名正常体重青少年。超重定义为年龄别体重指数（BMI/年龄）> +1标准差，包括体重超重和肥胖。根据摄入乳果糖后氢气和甲烷的产生情况，通过呼气试验诊断SIBO。连蛋白（触珠蛋白）被视为肠道通透性的指标。
超重青少年的身高/年龄Z评分（中位数[第25；第75百分位数]：+0.6[-0.4；+1.0]）高于正常体重组（-0.1[-0.6；+0.7]；P = 0.014）。超重青少年的连蛋白（mg/mL）（2.3[1.5；3.8]）高于正常体重青少年（1.6[1.0；2.2]）（P < 0.001）。133名青少年中有23.3%（31/133）被诊断为SIBO。与无SIBO的青少年相比，患有SIBO的青少年的BMI/年龄（+0.6[-0.6；+1.9]）和身高/年龄（-0.3[-0.7；+0.3]）较低（P < 0.05）（分别为+1.3[+0.1；+2.6]和+0.2[-0.5；+1.0]）。未发现连蛋白与SIBO之间存在关联。
超重与肠道通透性增加有关。未发现SIBO与肠道通透性之间存在关系；然而，SIBO与较低的BMI和年龄别身高Z评分有关。
