Nordby C A, Pelachyk J M, Burnham T K
Department of Dermatology, Henry Ford Hospital, Dearborn, MI 48126.
J Am Acad Dermatol. 1987 Sep;17(3):427-33. doi: 10.1016/s0190-9622(87)70224-2.
Fifty-one patients with lupus erythematosus were studied retrospectively. They were chosen on the basis of their antinuclear antibody (ANA) immunofluorescent pattern. Only those with the thready or the large speckle-like thready patterns were studied. Autoantibody profiles consisting of ANA, anti-single-stranded deoxyribonucleic acid (ssDNA) antibody, and anti-extractable nuclear antigen (ENA) antibody determinations were obtained. The patients with the thready ANA pattern and anti-ENA (Sm) antibodies had a significantly higher incidence of pulmonary, joint, and renal involvement than the anti-ENA negative patients with the large speckle-like thready pattern. There was also a significantly higher incidence of Raynaud's phenomenon in patients with the thready pattern than in those with the large speckle-like thready pattern. Photosensitivity was seen significantly more frequently in the patients with the large speckle-like thready pattern than in those with the thready pattern.
对51例红斑狼疮患者进行了回顾性研究。根据抗核抗体（ANA）免疫荧光模式选择患者。仅研究那些呈现线状或大斑点状线状模式的患者。检测了包括ANA、抗单链脱氧核糖核酸（ssDNA）抗体和抗可提取核抗原（ENA）抗体的自身抗体谱。呈现线状ANA模式且抗ENA（Sm）抗体阳性的患者，其肺部、关节和肾脏受累的发生率显著高于抗ENA阴性的大斑点状线状模式患者。线状模式患者雷诺现象的发生率也显著高于大斑点状线状模式患者。大斑点状线状模式患者的光敏性明显比线状模式患者更常见。
