Pelachyk J M, Heinzerling R, Burnham T K
Semin Arthritis Rheum. 1983 May;12(4):382-9. doi: 10.1016/0049-0172(83)90018-5.
The clinical and laboratory features of 55 patients with lupus erythematosus (LE), grouped on the basis of six nuclear immunofluorescent pattern results commonly encountered in this disease were examined. Serologic profiles of antinuclear antibodies (ANA), anti-DNA and anti-ENA results can serve as immunologic markers in LE for a benign subset and two other groups with a different incidence of certain clinical characteristics. The large speckle-like thready pattern without antibodies to DNA or ENA is an immunologic marker for a benign LE subset, with generalized skin lesions with or without joint involvement only. Significant levels of the anti-DNA antibodies with the shrunken peripheral, peripheral, or leukocyte-specific ANA with a particulate pattern are markers for severe systemic involvement. The thready pattern with antibodies to ENA (Sm antigen) and leukocyte-specific ANA without a particulate pattern, with or without antibodies to DNA or ENA, indicate less severe systemic disease.
对55例红斑狼疮（LE）患者的临床和实验室特征进行了检查，这些患者是根据该疾病中常见的六种核免疫荧光模式结果分组的。抗核抗体（ANA）、抗DNA和抗ENA结果的血清学谱可作为LE中一个良性亚组和另外两组具有不同某些临床特征发生率的免疫标志物。无抗DNA或抗ENA抗体的大斑点状细丝状模式是良性LE亚组的免疫标志物，仅伴有或不伴有关节受累的全身性皮肤病变。具有外周收缩型、外周型或白细胞特异性ANA且呈颗粒状模式的抗DNA抗体显著升高是严重全身受累的标志物。有抗ENA（Sm抗原）抗体的细丝状模式和无颗粒状模式的白细胞特异性ANA，无论有无抗DNA或抗ENA抗体，均提示全身疾病较轻。
