Thomas Aline, Baillet Marion, Proust-Lima Cécile, Féart Catherine, Foubert-Samier Alexandra, Helmer Catherine, Catheline Gwénaëlle, Samieri Cécilia
INSERM, BPH, U1219, Univ. Bordeaux, Bordeaux, F-33000, France.
Institut des Maladies Neurodégénératives, Bordeaux Univ. Hospital, Bordeaux, F-33000, France.
Alzheimers Dement. 2020 Oct 8. doi: 10.1002/alz.12195.
We searched for consistent associations of an omega-3 index in plasma (sum of eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) with several dementia-related outcomes in a large cohort of older adults.
We included 1279 participants from the Three-City study, non-demented at the time of blood measurements at baseline, with face-to-face neuropsychological assessment and systematic detection of incident dementia over a 17-year follow-up. An ancillary study included 467 participants with up to three repeated brain imaging exams over 10 years.
In multivariable models, higher levels of plasma EPA+DHA were consistently associated with a lower risk of dementia (hazard ratio for 1 standard deviation = 0.87 [95% confidence interval, 0.76-0.98]), and a lower decline in global cognition (P = .04 for change over time), memory (P = .06), and medial temporal lobe volume (P = .02).
This prospective study provides compelling evidence for a relationship between long-chain omega-3 fatty acids levels and lower risks for dementia and related outcomes.
我们在一大群老年人中，探寻血浆中ω-3指数（二十碳五烯酸[EPA]和二十二碳六烯酸[DHA]的总和）与几种痴呆相关结局之间的一致性关联。
我们纳入了来自三城市研究的1279名参与者，他们在基线血液测量时未患痴呆，在17年的随访期间接受了面对面神经心理学评估和新发痴呆的系统检测。一项辅助研究纳入了467名参与者，他们在10年内接受了多达三次重复的脑成像检查。
在多变量模型中，血浆EPA+DHA水平较高始终与较低的痴呆风险相关（1个标准差的风险比=0.87[95%置信区间，0.76-0.98]），并且与整体认知（随时间变化P=0.04）、记忆（P=0.06）和内侧颞叶体积（P=0.02）的下降幅度较小相关。
这项前瞻性研究为长链ω-3脂肪酸水平与较低的痴呆风险及相关结局之间的关系提供了有力证据。
