Foshan Stomatological Hospital, School of Stomatology and Medicine, Foshan University, Foshan, Guangdong, China.
J Cell Mol Med. 2020 Nov;24(22):13266-13277. doi: 10.1111/jcmm.15943. Epub 2020 Oct 14.
Circular RNAs (circRNAs) represent a newly discovered class of endogenous non-coding RNAs which are widely expressed and play important roles in disease progression. However, the function of circRNAs in oral squamous cell carcinoma (OSCC) still remains largely unknown. In this research, we found that circ_SEPT9 was highly expressed in OSCC cell lines and tumour tissues. Results showed that circ_SEPT9 promoted OSCC proliferation and tumour growth. And, circ_SEPT9 also enhanced the migration and invasion of OSCC cells. Mechanically, we found that circ_SEPT9 acted as a sponge for miR-1225 to rescue PKN2 expression in OSCC cells. Inhibition of circ_SEPT9/miR-1225/PKN2 pathway could effectively block the proliferation and metastasis of OSCC cells. Our study provides strong evidence that circ_SEPT9/miR-1225/PKN2 axis is a promising target for OSCC treatment.
环状 RNA（circRNAs）是一类新发现的内源性非编码 RNA，广泛表达并在疾病进展中发挥重要作用。然而，circRNAs 在口腔鳞状细胞癌（OSCC）中的功能仍知之甚少。在这项研究中，我们发现 circ_SEPT9 在 OSCC 细胞系和肿瘤组织中高表达。结果表明 circ_SEPT9 促进了 OSCC 的增殖和肿瘤生长。并且，circ_SEPT9 还增强了 OSCC 细胞的迁移和侵袭。从机制上讲，我们发现 circ_SEPT9 作为 miR-1225 的海绵，挽救了 OSCC 细胞中 PKN2 的表达。抑制 circ_SEPT9/miR-1225/PKN2 通路可以有效阻断 OSCC 细胞的增殖和转移。我们的研究为 circ_SEPT9/miR-1225/PKN2 轴作为 OSCC 治疗的有前途的靶点提供了有力证据。
