Maury C P, Teppo A M
Fourth Department of Medicine, University of Helsinki, Finland.
J Exp Med. 1987 Oct 1;166(4):1132-7. doi: 10.1084/jem.166.4.1132.
A sensitive radioimmunoassay was used for monitoring serum levels of endogenous cachectin/tumor necrosis factor alpha (TNF) in 10 renal transplant recipients. Acute allograft rejections were associated with marked elevations of circulating TNF. The peak levels of TNF (median 140 pg/ml) were in the same concentration range as previously reported in parasitic infections. The results show that the release of TNF into circulation is an early event in renal allograft rejection and that raised levels of TNF in man can also be induced by noninfectious stimuli.
采用灵敏的放射免疫分析法监测10例肾移植受者血清中内源性恶病质素/肿瘤坏死因子α（TNF）的水平。急性移植肾排斥反应与循环中TNF的显著升高相关。TNF的峰值水平（中位数为140 pg/ml）与先前报道的寄生虫感染时的浓度范围相同。结果表明，TNF释放进入循环是肾移植排斥反应中的早期事件，而且人体中TNF水平升高也可由非感染性刺激诱导产生。
